Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | DRD3 | P35462 | 4/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737305 | 0.93 | DRD4 (0.45) | KDM4EALDH1A1TSHRHTTSMN1; SMN2 | |
| SCHEMBL4738909 | 0.90 | TSHR (0.44) | KDM4EALDH1A1TSHRCETPMEN1 | |
| SCHEMBL4738924 | 0.90 | OPRM1 (0.40) | KDM4EALDH1A1TSHRL3MBTL1SMN1; SMN2 | |
| SCHEMBL4735426 | 0.90 | OPRM1 (0.43) | KDM4EALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL4736584 | 0.89 | TSHR (0.51) | KDM4EALDH1A1TSHRL3MBTL1SLC6A7 | |
| SCHEMBL4737014 | 0.88 | HDAC2 (0.42) | KDM4EALDH1A1TSHRMAPK14OPRM1 | |
| SCHEMBL4733666 | 0.88 | OPRM1 (0.49) | KDM4EALDH1A1TSHRL3MBTL1MAPK14 | |
| SCHEMBL4737659 | 0.86 | KDM4E (0.47) | KDM4EALDH1A1TSHRSMN1; SMN2MAPK14 | |
| SCHEMBL4735549 | 0.86 | MEN1 (0.43) | KDM4EALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL4735517 | 0.85 | MAPK14 (0.38) | KDM4EALDH1A1TSHRL3MBTL1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |