Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 6/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | ME2 | P23368 | 1/20 | 0.38 |
| ▸ | ME1 | P48163 | 1/20 | 0.38 |
| ▸ | ME3 | Q16798 | 1/20 | 0.38 |
| ▸ | MLNR | O43193 | 2/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735426 | 0.90 | OPRM1 (0.43) | MAPK14OPRM1OPRK1ME2ME1 | |
| SCHEMBL4738924 | 0.89 | OPRM1 (0.40) | MAPK14HDAC10OPRM1OPRK1ME2 | |
| SCHEMBL4735517 | 0.88 | MAPK14 (0.38) | MAPK14OPRM1OPRK1ME2ME1 | |
| SCHEMBL4733795 | 0.88 | KDM4E (0.51) | MAPK14OPRM1OPRK1ME2ME1 | |
| SCHEMBL4737305 | 0.88 | DRD4 (0.45) | MAPK14CXCR2KDM4EALDH1A1TSHR | |
| SCHEMBL4738909 | 0.87 | TSHR (0.44) | MAPK14OPRM1OPRK1ME2ME1 | |
| SCHEMBL3826843 | 0.86 | MAPKAPK2 (0.47) | HDAC2HDAC3HDAC1HDAC10HDAC6 | |
| SCHEMBL4733666 | 0.85 | OPRM1 (0.49) | MAPK14OPRM1OPRK1KDM4EALDH1A1 | |
| SCHEMBL4738700 | 0.84 | MAPK14 (0.39) | MAPK14MLNRCXCR2KDM4EALDH1A1 | |
| SCHEMBL4735512 | 0.84 | HRH3 (0.43) | MAPK14OPRM1OPRK1ME2ME1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |