Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 2/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737143 | 0.93 | TDP1 (0.38) | ALDH1A1SMN1; SMN2MAOBALPLALPI | |
| SCHEMBL4733748 | 0.89 | — | — | |
| SCHEMBL4733429 | 0.87 | CYP1A1 (0.33) | ALDH1A1 | |
| SCHEMBL4735344 | 0.87 | ADORA2B (0.30) | — | |
| SCHEMBL4805989 | 0.86 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4784960 | 0.83 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2MAOBALPLTDP1 | |
| SCHEMBL4734992 | 0.80 | MMP2 (0.31) | — | |
| SCHEMBL4738183 | 0.78 | MMP2 (0.33) | — | |
| SCHEMBL4784356 | 0.76 | BACE1 (0.58) | — | |
| SCHEMBL4735172 | 0.76 | DRD2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076046-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |