Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 5/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4735240 | 0.91 | KDM4E (0.44) | HTTDRD4TMEM97SIGMAR1HTR1A | |
| SCHEMBL4737963 | 0.89 | MEN1 (0.39) | LMNAMAPTDRD4HTR1ACYP1A2 | |
| SCHEMBL4739654 | 0.87 | LMNA (0.38) | LMNAHTTNPC1MAPTRAB9A | |
| SCHEMBL4738694 | 0.86 | ACHE (0.43) | LMNAMAPTDRD4SIGMAR1DRD2 | |
| SCHEMBL4739647 | 0.85 | AR (0.43) | LMNAHTTNPC1MAPTRAB9A | |
| SCHEMBL4737079 | 0.85 | MEN1 (0.38) | HTTMAPTCXCR2KDM4EALDH1A1 | |
| SCHEMBL4734180 | 0.85 | KDM4E (0.41) | KDM4EALDH1A1TSHR | |
| SCHEMBL3060048 | 0.83 | LMNA (0.44) | LMNAHTTNPC1MAPTRAB9A | |
| SCHEMBL4737001 | 0.83 | CYP3A4 (0.37) | LMNAHTTMAPTMAPK1HTR1A | |
| SCHEMBL4735114 | 0.83 | SMN1; SMN2 (0.41) | LMNAHTTNPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |