Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 14/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 13/20 | 1.00 |
| ▸ | USP2 | O75604 | 13/20 | 1.00 |
| ▸ | CLK4 | Q9HAZ1 | 12/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 10/20 | 1.00 |
| ▸ | LMNA | P02545 | 10/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 1.00 |
| ▸ | MEN1 | O00255 | 9/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 9/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 9/20 | 1.00 |
| ▸ | TSHR | P16473 | 7/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.69 |
| ▸ | RAF1 | P04049 | 4/20 | 0.67 |
| ▸ | BRAF | P15056 | 4/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15051337 | 0.85 | BRAF (0.84) | CYP1A2CYP3A4USP2CLK4CYP2D6 | |
| SCHEMBL1675019 | 0.81 | CLK4 (1.00) | CYP1A2CYP3A4USP2CLK4CYP2D6 | |
| SCHEMBL15051638 | 0.81 | EGFR (0.78) | CYP1A2CYP3A4USP2CLK4CYP2D6 | |
| SCHEMBL6186515 | 0.80 | MEN1 (0.74) | CYP1A2CYP3A4USP2CLK4CYP2D6 | |
| SCHEMBL15051491 | 0.80 | BRAF (1.00) | CYP1A2CYP3A4USP2CLK4CYP2D6 | |
| SCHEMBL15052375 | 0.77 | BRAF (0.82) | CYP1A2CYP3A4USP2CLK4CYP2D6 | |
| SCHEMBL4350939 | 0.76 | EGFR (0.67) | CYP1A2CYP3A4USP2CLK4CYP2D6 | |
| SCHEMBL15077856 | 0.76 | BRAF (0.65) | CYP1A2CYP3A4USP2CLK4CYP2D6 | |
| SCHEMBL15051632 | 0.76 | BRAF (0.73) | CYP1A2CYP3A4USP2CLK4CYP2D6 | |
| SCHEMBL15052369 | 0.75 | CLK4 (1.00) | CYP1A2CYP3A4USP2CLK4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089307-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF PAIN, INFLAMMATION AND CANCER | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | claimed |
| WO-2008089310-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF OBESITY | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | claimed |
| US-20240216316-A1 | DIHOMO-GAMMA LINOLENIC ACID (DGLA) IS A NOVEL SENOLYTIC | BUCK INST RES AGING (US) | 2024-07-04 | — | — | US | disclosed |
| US-20080200458-A1 | Methods and compositions for the treatment of body composition disorders | LEXICON PHARMACEUTICALS, INC. | 2008-08-21 | — | — | US | disclosed |
| US-20080194557-A1 | Methods and compositions for the treatment of pain, inflammation and cancer | LEXICON PHARMACEUTICALS, INC. | 2008-08-14 | — | — | US | disclosed |
| WO-2008089310-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF OBESITY | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008089307-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF PAIN, INFLAMMATION AND CANCER | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194557-A1 | Methods and compositions for the treatment of pain, inflammation and cancer | TNF, IL6, CXCL8 | CYP1A2 1592/4885CYP3A4 2431/4885USP2 2356/4885 |
| US-20240216316-A1 | DIHOMO-GAMMA LINOLENIC ACID (DGLA) IS A NOVEL SENOLYTIC | DAGLA, DAGLB, MGLL | CYP1A2 3697/4885CYP3A4 4330/4885USP2 227/4885 |
| US-20080200458-A1 | Methods and compositions for the treatment of body composition disorders | CPT1B, CPT1A, SHBG | CYP1A2 610/4885CYP3A4 1242/4885USP2 2668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.