Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | KLK1 | P06870 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | FPR1 | P21462 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787168 | 0.90 | TSHR (0.45) | TSHRGAAPDK1MAPK14CXCR2 | |
| SCHEMBL4735235 | 0.90 | GAA (0.47) | TSHRGAAPDK1MAPK14CXCR2 | |
| SCHEMBL4736736 | 0.88 | CDK9 (0.44) | TSHRGAAPDK1MAPK14CXCR2 | |
| SCHEMBL4735150 | 0.87 | TSHR (0.51) | TSHRGAAPDK1MAPK14CXCR2 | |
| SCHEMBL4786168 | 0.86 | TSHR (0.47) | TSHRGAAPDK1KLKB1KLK1 | |
| SCHEMBL4738289 | 0.85 | GAA (0.45) | TSHRGAAPDK1MAPK14CXCR2 | |
| SCHEMBL4737958 | 0.85 | TSHR (0.48) | TSHRGAAPDK1MAPK14CXCR2 | |
| SCHEMBL3059465 | 0.84 | ACHE (0.40) | TSHRKMT2AKDM4EALDH1A1FPR1 | |
| SCHEMBL4735626 | 0.83 | TSHR (0.42) | TSHRGAAPDK1MAPK14KDM4E | |
| SCHEMBL4733572 | 0.83 | TSHR (0.45) | TSHRGAAPDK1MAPK14CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |