SCHEMBL473923

SCHEMBL473923

O=C(O)Cc1ccc(Br)cc1Cl

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GRIK1 P39086 1/20 0.46
CAMK2A Q9UQM7 3/20 0.43
AKR1B1 P15121 1/20 0.42
CA2 P00918 1/20 0.42
PYCR1 P32322 1/20 0.41
CXCL8 P10145 2/20 0.41
DGAT1 O75907 1/20 0.41
MGAM O43451 1/20 0.40
GAA P10253 1/20 0.40
SI P14410 1/20 0.40
MGAM2 Q2M2H8 1/20 0.40
PTGDR2 Q9Y5Y4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29899638 1.00 GRIK1 (0.46) GRIK1CAMK2AAKR1B1CA2PYCR1
SCHEMBL154416 0.85 PTGDR2 (0.44) GRIK1CAMK2AAKR1B1CA2CXCL8
SCHEMBL1350652 0.83 PYCR1 (0.44) PYCR1MGAMGAASIMGAM2
SCHEMBL2951923 0.83 PYCR1 (0.41) PYCR1DGAT1MGAMGAASI
SCHEMBL20567700 0.81 SRC (0.59) CAMK2AAKR1B1CA2CXCL8DGAT1
SCHEMBL30917833 0.80 F13A1 (0.44)
SCHEMBL260512 0.80 CHRM1 (0.57) CXCL8
SCHEMBL10479066 0.80 PTGDR2 (0.42) GRIK1AKR1B1PYCR1PTGDR2
SCHEMBL6456130 0.80 AKR1B1 (0.52) GRIK1CAMK2AAKR1B1GAAPTGDR2
SCHEMBL29419329 0.80 CHRM1 (0.57) CXCL8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 150 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101208347-B Method of preparing clopidogrel and intermediates used therein HANMI PHARM IND CO LTD 2011-01-12 CN claimed
CN-101208347-A Method of preparing clopidogrel and intermediates used therein HANMI PHARM IND CO LTD (KR) 2008-06-25 CN claimed
CN-100390180-C Clopidogrel and its salt preparing method SHANGHAI APPLIED TECHNOLOGY CO (CN) 2008-05-28 CN claimed
CN-1775782-A Clopidogrel and its salt preparing method SHANGHAI APPLIED TECHNOLOGY CO (CN) 2006-05-24 CN claimed
US-12509474-B2 Inhibitors of complement factors and uses thereof ANNEXON, INC. (US) 2025-12-30 US disclosed
EP-4572755-A2 CDK2 DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2025-06-25 EP disclosed
WO-2025006553-A1 METABOTROPIC GLUTAMATE RECEPTOR POSITIVE ALLOSTERIC MODULATORS AND USES THEREOF Sanford Burnham Prebys Medical Discovery Institute (US) 2025-01-02 WO disclosed
US-20240173419-A1 CDK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2024-05-30 US disclosed
WO-2024067560-A1 SULFONAMIDE COMPOUND AND MEDICAL USE THEREOF 中国药科大学 2024-04-04 WO disclosed
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF ANNEXON, INC. 2024-04-04 US disclosed
WO-2024039901-A2 CDK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2024-02-22 WO disclosed
WO-2024009232-A1 SUBSTITUTED N-(PYRIDIN-2-YL)ACETAMIDE DERIVATIVES AS CDK12/13 INHIBITORS AURIGENE ONCOLOGY LIMITED (IN) 2024-01-11 WO disclosed
CN-1775782-A Clopidogrel and its salt preparing method SHANGHAI APPLIED TECHNOLOGY CO (CN) 2006-05-24 CN disclosed
US-20050288318-A1 Pyridoindolone derivatives substituted in the 3-position by a phenyl, their preparation and their application in therapeutics SANOFI-AVENTIS (FR) 2005-12-29 US disclosed
EP-1556382-A1 3-PHENYL SUBSTITUTED PYRIDOINDOLONE, PREPARATION AND THERAPEUTIC USE THEREOF Sanofi-Aventis (FR) 2005-07-27 EP disclosed
WO-2004041817-A1 3-PHENYL SUBSTITUTED PYRIDOINDOLONE, PREPARATION AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2004-05-21 WO disclosed
EP-1077701-A4 ANTI-VIRAL COMPOUNDS LILLY CO ELI (US) 2002-03-20 EP disclosed
CN-1292697-A Anti-viral compound LILLY CO ELI (US) 2001-04-25 CN disclosed
EP-1077701-A1 ANTI-VIRAL COMPOUNDS ELI LILLY AND COMPANY (US) 2001-02-28 EP disclosed
WO-1999059587-A1 ANTI-VIRAL COMPOUNDS ELI LILLY AND COMPANY (US) 1999-11-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240109920-A1 INHIBITORS OF COMPLEMENT FACTORS AND USES THEREOF CFB, CFH, C9 GRIK1 1887/4885CAMK2A 4033/4885AKR1B1 610/4885
US-20050288318-A1 Pyridoindolone derivatives substituted in the 3-position by a phenyl, their preparation and their application in therapeutics PNPO, PDXK, PLPBP GRIK1 2801/4885CAMK2A 2986/4885AKR1B1 102/4885
US-12509474-B2 Inhibitors of complement factors and uses thereof SSB, UACA, CFH GRIK1 1418/4885CAMK2A 1990/4885AKR1B1 2707/4885
US-20240173419-A1 CDK2 DEGRADERS AND USES THEREOF CDK2, CDK20, CDK1 GRIK1 3991/4885CAMK2A 787/4885AKR1B1 1831/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.