Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYCR1 | P32322 | 1/20 | 0.64 |
| ▸ | APLNR | P35414 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739246 | 0.79 | CALM1 (0.56) | SMN1; SMN2AOC3IDO1MEN1KMT2A | |
| SCHEMBL4611890 | 0.77 | PYCR1 (0.69) | PYCR1APLNRLMNAMAPTALDH1A1 | |
| SCHEMBL385286 | 0.77 | HRH3 (0.58) | PYCR1APLNRLMNAMAPTALDH1A1 | |
| SCHEMBL27210386 | 0.76 | PYCR1 (0.72) | PYCR1APLNRALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL5270803 | 0.74 | APLNR (0.59) | PYCR1APLNRLMNAMAPTALDH1A1 | |
| SCHEMBL12049800 | 0.74 | APLNR (0.59) | PYCR1APLNRLMNAMAPTALDH1A1 | |
| SCHEMBL28074567 | 0.74 | IDO1 (0.56) | PYCR1APLNRLMNAMAPTALDH1A1 | |
| SCHEMBL10049173 | 0.74 | AOC3 (0.66) | PYCR1APLNRLMNAMAPTALDH1A1 | |
| SCHEMBL27995373 | 0.74 | ALDH1A1 (0.56) | PYCR1APLNRLMNAMAPTALDH1A1 | |
| SCHEMBL7297850 | 0.74 | PYCR1 (0.55) | PYCR1APLNRLMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417190-B1 | SUBSTITUTED PIPERAZINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEN INC (US) | 2008-10-22 | — | — | EP | claimed |
| EP-1416933-B1 | SUBSTITUTED PIPERIDINES AS MODULATORS OF THE MELANOCORTIN RECEPTOR | AMGEM INC (US) | 2008-01-02 | — | — | EP | claimed |