Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740409 | 0.91 | CYP19A1 (0.47) | LMNATP53CYP19A1CYP3A4CYP2C19 | |
| SCHEMBL4738940 | 0.91 | ALDH1A1 (0.53) | CYP19A1CYP3A4CYP2C19POLBALDH1A1 | |
| SCHEMBL4739879 | 0.89 | RAB9A (0.58) | LMNATP53POLBALDH1A1KDM4E | |
| SCHEMBL4740145 | 0.86 | MAPT (0.49) | TP53CYP19A1CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL4740901 | 0.86 | CYP19A1 (0.58) | LMNATP53CYP19A1CYP3A4CYP2C19 | |
| SCHEMBL4738918 | 0.85 | CYP3A4 (0.67) | LMNATP53CYP19A1CYP3A4CYP2C19 | |
| SCHEMBL4740143 | 0.85 | CYP3A4 (0.67) | LMNATP53CYP19A1CYP3A4CYP2C19 | |
| SCHEMBL4739860 | 0.85 | ALDH1A1 (0.55) | CYP3A4CYP2C19POLBALDH1A1KDM4E | |
| SCHEMBL4739753 | 0.84 | CYP3A4 (0.68) | LMNATP53CYP19A1CYP3A4CYP2C19 | |
| SCHEMBL4741708 | 0.84 | ALDH1A1 (0.56) | CYP3A4CYP2C19POLBALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | claimed |