Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740197 | 0.91 | LMNA (0.50) | CYP19A1CYP3A4CYP2C19KDM4EKMT2A | |
| SCHEMBL4739834 | 0.87 | CYP3A4 (0.61) | CYP19A1CYP3A4CYP2C19KMT2AMEN1 | |
| SCHEMBL4738940 | 0.87 | ALDH1A1 (0.53) | CYP19A1CYP3A4CYP2C19KDM4EKMT2A | |
| SCHEMBL4782859 | 0.84 | SMN1; SMN2 (0.50) | CYP19A1CYP3A4CYP2C19KDM4EKMT2A | |
| SCHEMBL4739879 | 0.81 | RAB9A (0.58) | KDM4EKMT2AMEN1MAPTTP53 | |
| SCHEMBL4738947 | 0.79 | CYP3A4 (0.64) | CYP19A1CYP3A4CYP2C19KDM4EKMT2A | |
| SCHEMBL4738938 | 0.78 | TSHR (0.56) | CYP19A1KMT2AMEN1MAPTTP53 | |
| SCHEMBL4740145 | 0.78 | MAPT (0.49) | CYP19A1CYP3A4CYP2C19KDM4EKMT2A | |
| SCHEMBL4740901 | 0.78 | CYP19A1 (0.58) | CYP19A1CYP3A4CYP2C19KDM4EKMT2A | |
| SCHEMBL4740148 | 0.78 | TSHR (0.50) | KMT2AMEN1TP53POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087654-A2 | PIPERIDINES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 | CADILA HEALTHCARE LIMITED (IN) | 2008-07-24 | — | — | WO | disclosed |