Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.61 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11631684 | 0.89 | L3MBTL1 (0.62) | TDP1KEAP1KMT2ARAB9AALDH1A1 | |
| SCHEMBL9318015 | 0.86 | LMNA (0.56) | TDP1KMT2ASLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL1739439 | 0.86 | TDP1 (0.73) | TDP1KEAP1KMT2ASLC6A3RAB9A | |
| SCHEMBL27327027 | 0.86 | NPC1 (0.70) | TDP1KMT2ARAB9AALDH1A1NPC1 | |
| SCHEMBL6567861 | 0.85 | RAB9A (0.55) | TDP1KMT2ARAB9AALDH1A1NPC1 | |
| Water SCHEMBL21440321 | 0.84 | LMNA (0.54) | TDP1KMT2ASLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL27192192 | 0.84 | LMNA (0.54) | TDP1KMT2ASLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL15485653 | 0.84 | LMNA (0.54) | TDP1KMT2ASLC6A2SLC6A3RAB9A | |
| SCHEMBL7758809 | 0.82 | TDP1 (0.53) | TDP1KMT2ASLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL29172840 | 0.82 | TDP1 (0.53) | TDP1KMT2ASLC6A2SLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735178-B2 | Withanolides, probes and binding targets and methods of use thereof | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2014-05-27 | — | — | US | claimed |
| US-20080207574-A1 | WITHANOLIDES, PROBES AND BINDING TARGETS AND METHODS OF USE THEREOF | KENTUCKY RESEARCH FOUNDATION | 2008-08-28 | — | — | US | claimed |
| WO-2008101109-A1 | WITHANOLIDES, PROBES AND BINDING TARGETS AND METHODS OF USE THEREOF | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2008-08-21 | — | — | WO | claimed |
| EP-1100479-B1 | MEDICINAL PRODUCTS WITH RETARDED PHARMACOLOGICAL ACTIVITY AND METHOD FOR THE PRODUCTION THEREOF | SCHIERHOLZ JOERG DR DR (DE) | 2006-01-11 | — | — | EP | claimed |
| CN-105693763-B | A kind of organotin complex of the ligand containing acylhydrazone and its preparation method and application | 衡阳师范学院 | 2018-09-14 | — | — | CN | disclosed |
| CN-105541898-B | A kind of phenylpropionic acid benzoyl hydrazone two of 2 carbonyl 3 is to methyl-benzyl tin complex and its preparation method and application | 衡阳师范学院 | 2018-02-09 | — | — | CN | disclosed |
| CN-105541898-B | A kind of phenylpropionic acid benzoyl hydrazone two of 2 carbonyl 3 is to methyl-benzyl tin complex and its preparation method and application | 衡阳师范学院 | 2018-02-09 | — | — | CN | disclosed |
| EP-3180317-A1 | FACTOR XIa INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2017-06-21 | — | — | EP | disclosed |
| WO-2016015593-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-02-04 | — | — | WO | disclosed |
| US-8735178-B2 | Withanolides, probes and binding targets and methods of use thereof | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2014-05-27 | — | — | US | disclosed |
| US-20080207574-A1 | WITHANOLIDES, PROBES AND BINDING TARGETS AND METHODS OF USE THEREOF | KENTUCKY RESEARCH FOUNDATION | 2008-08-28 | — | — | US | disclosed |
| WO-2008101109-A1 | WITHANOLIDES, PROBES AND BINDING TARGETS AND METHODS OF USE THEREOF | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2008-08-21 | — | — | WO | disclosed |
| WO-2007084386-A1 | PHOTOCURABLE HYGROSCOPIC COMPOSITION AND ORGANIC EL DEVICE | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2007-07-26 | — | — | WO | disclosed |
| US-4111997-A | ANTIPYRETIC, ANALGESIC, ANTIINFLAMMATORY | TAKEDA CHEMICAL COMPANY, LTD. (JP) | 1978-09-05 | — | — | US | disclosed |
| US-4007225-A | ANTIPYRETIC, ANALGESIC, ANTIINFLAMMATORY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1977-02-08 | — | — | US | disclosed |
| US-3953500-A | ANTIPYRETICS, ANALGESICS, ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1976-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207574-A1 | WITHANOLIDES, PROBES AND BINDING TARGETS AND METHODS OF USE THEREOF | VIM, HASPIN, FABP3 | TDP1 4635/4885KEAP1 169/4885KMT2A 3568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.