Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | CASP1 | P29466 | 2/20 | 0.48 |
| ▸ | CASP7 | P55210 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | GLA | P06280 | 3/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28557478 | 0.85 | ALDH1A1 (0.59) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL28544942 | 0.81 | KMT2A (0.59) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL29779736 | 0.77 | CRHBP (0.47) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL4886697 | 0.73 | CRHBP (0.47) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL4884454 | 0.72 | CRHBP (0.43) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL15987314 | 0.71 | TSHR (0.61) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL7878712 | 0.71 | TSHR (0.58) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL15997829 | 0.71 | NOTUM (0.56) | MEN1KMT2AKDM4EALDH1A1GAA | |
| SCHEMBL17060360 | 0.70 | CCR2 (0.54) | MAPTTHRB | |
| SCHEMBL21333196 | 0.70 | LMNA (0.59) | MEN1KMT2AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008073461-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |