Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | KCNQ3 | O43525 | 7/20 | 0.56 |
| ▸ | KCNQ2 | O43526 | 7/20 | 0.56 |
| ▸ | KCNE1 | P15382 | 6/20 | 0.56 |
| ▸ | KCNQ1 | P51787 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4177141 | 0.89 | RAB9A (0.68) | RAB9ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL24891741 | 0.82 | MEN1 (0.63) | RAB9ASMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL28049871 | 0.82 | L3MBTL1 (0.72) | RAB9ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL1986996 | 0.81 | KCNQ3 (0.82) | RAB9ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL5215207 | 0.81 | KCNQ3 (0.81) | RAB9ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL3313800 | 0.80 | RAB9A (0.75) | RAB9ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL28049980 | 0.79 | RAB9A (0.57) | RAB9ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL2801974 | 0.79 | KCNQ3 (0.85) | RAB9ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL8361559 | 0.79 | RAB9A (1.00) | RAB9ASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL2306301 | 0.78 | RAB9A (0.76) | RAB9ASMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086462-A2 | AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF β-CANTENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS | WYETH (US) | 2008-07-17 | — | — | WO | disclosed |