Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 2/20 | 0.59 |
| ▸ | PARP1 | P09874 | 3/20 | 0.58 |
| ▸ | DHODH | Q02127 | 2/20 | 0.53 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 4/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | CCND1 | P24385 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16638382 | 0.87 | DHODH (0.70) | GUSBPARP1DHODHCYP1A1CYP1B1 | |
| SCHEMBL9131496 | 0.81 | RARA (0.55) | GUSBPARP1DHODHCYP1A1CYP1B1 | |
| SCHEMBL505569 | 0.81 | DHODH (0.55) | PARP1DHODHKDM4EALDH1A1HPGD | |
| SCHEMBL30424707 | 0.80 | GUSB (0.57) | GUSBPARP1CYP1A1CYP1B1CYP1A2 | |
| SCHEMBL696548 | 0.79 | DHODH (0.56) | PARP1DHODHCYP1A2KDM4EALDH1A1 | |
| SCHEMBL505273 | 0.78 | PARP1 (0.52) | PARP1DHODHKDM4EALDH1A1HPGD | |
| SCHEMBL3586495 | 0.78 | ADORA2A (0.56) | GUSBPARP1PDE4APDE4BPDE4C | |
| SCHEMBL15958954 | 0.78 | PARP1 (0.62) | GUSBPARP1DHODHKDM4EALDH1A1 | |
| SCHEMBL6840289 | 0.77 | PIN1 (0.56) | PARP1DHODHKDM4EALDH1A1HPGD | |
| SCHEMBL6840189 | 0.77 | PIN1 (0.58) | DHODHKDM4EALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008100376-A2 | TRUNCATION VARIANTS OF SIRT1 AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2008-08-21 | — | — | WO | disclosed |
| WO-2008100376-A2 | TRUNCATION VARIANTS OF SIRT1 AND METHODS OF USE THEREOF | SIRTRIS PHARMACEUTICALS, INC. (US) | 2008-08-21 | — | — | WO | disclosed |