Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPEP | Q07075 | 4/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17433678 | 0.82 | CA2 (0.37) | MAPTRIPK1 | |
| SCHEMBL4290322 | 0.77 | KIF11 (0.33) | RIPK1 | |
| SCHEMBL8460951 | 0.77 | TSHR (0.32) | RIPK1 | |
| SCHEMBL14470035 | 0.74 | MAPK1 (0.39) | KDM4EALDH1A1 | |
| SCHEMBL4053641 | 0.73 | TP53 (0.33) | PTGS1MAPTALDH1A1RIPK1 | |
| SCHEMBL1666550 | 0.72 | RNPEP (0.46) | KDM4EALOX15ALDH1A1 | |
| SCHEMBL8461977 | 0.71 | RNPEP (0.33) | — | |
| SCHEMBL23383641 | 0.70 | RIPK1 (0.31) | RIPK1 | |
| SCHEMBL1664400 | 0.70 | RIPK1 (0.31) | RIPK1 | |
| SCHEMBL15656492 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10793884-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-10-06 | — | — | US | disclosed |
| US-20180355391-A1 | METHODS AND MATERIALS FOR MAKING SIMVASTATIN AND RELATED COMPOUNDS | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2018-12-13 | — | — | US | disclosed |
| US-9970037-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-05-15 | — | — | US | disclosed |
| US-20150203884-A1 | METHODS AND MATERIALS FOR MAKING SIMVASTATIN AND RELATED COMPOUNDS | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2015-07-23 | — | — | US | disclosed |
| US-8951754-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-02-10 | — | — | US | disclosed |
| CN-101490271-B | Methods and materials for making simvastatin and related compounds | UNIV CALIFORNIA | 2014-03-12 | — | — | CN | disclosed |
| US-20120315680-A1 | METHODS AND MATERIALS FOR MAKING SIMVASTATIN AND RELATED COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-12-13 | — | — | US | disclosed |
| US-8211664-B2 | Methods and materials for making simvastatin and related compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-03 | — | — | US | disclosed |
| EP-2032715-B1 | Methods and materials for making simvastatin and related compounds | UNIV CALIFORNIA (US) | 2012-02-01 | — | — | EP | disclosed |
| US-20090191602-A1 | Methods and Materials for Making Simvastatin and Related Compounds | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2009-07-30 | — | — | US | disclosed |
| CN-101490271-A | Methods and materials for making simvastatin and related compounds | UNIV CALIFORNIA (US) | 2009-07-22 | — | — | CN | disclosed |
| EP-2032715-A2 | METHODS AND MATERIALS FOR MAKING SIMVASTATIN AND RELATED COMPOUNDS | The Regents of the University of California (US) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007139871-A2 | METHODS AND MATERIALS FOR MAKING SIMVASTATIN AND RELATED COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-12-06 | — | — | WO | disclosed |