Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 9/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | FPR1 | P21462 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4741286 | 0.74 | MAPT (0.36) | LMNAPKMADORA2AADORA2BUSP2 | |
| SCHEMBL4741309 | 0.72 | KMT2A (0.39) | LMNAUSP2KDM4EMAPT | |
| SCHEMBL4741265 | 0.72 | NPC1 (0.50) | KDM4E | |
| SCHEMBL4740498 | 0.71 | CCR2 (0.41) | — | |
| SCHEMBL4740381 | 0.70 | MDM2 (0.47) | KDM4E | |
| SCHEMBL4784797 | 0.69 | APLNR (0.48) | LMNAUSP2GAAKDM4EMAPT | |
| SCHEMBL4739176 | 0.68 | TSHR (0.50) | LMNAPKMHSD17B10KDM4EMAPT | |
| SCHEMBL17401503 | 0.68 | ENPP2 (0.57) | — | |
| SCHEMBL4741829 | 0.67 | APLNR (0.50) | USP2KDM4EHPGD | |
| SCHEMBL4737525 | 0.67 | KMT2A (0.54) | LMNAPKMUSP2GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089051-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES: PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | disclosed |