SCHEMBL4742259

SCHEMBL4742259

Cc1c(/N=N/c2c(C#N)cnn2-c2ncccn2)c(O)n(C)c(=O)c1C#N

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.38
MEN1 O00255 7/20 0.38
KMT2A Q03164 7/20 0.38
ALDH1A1 P00352 4/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
KDM4E B2RXH2 5/20 0.37
GAA P10253 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
PKM P14618 1/20 0.32
MITF O75030 1/20 0.32
THRB P10828 1/20 0.32
LMNA P02545 1/20 0.30
KDM5A P29375 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4743198 1.00 MAPT (0.38) MAPTMEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL4781146 0.91 MAPT (0.40) MAPTMEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL4742314 0.89 MAPT (0.39) MAPTMEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL4742312 0.84 MEN1 (0.37) MAPTMEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL4742276 0.82 KMT2A (0.41) MAPTMEN1KMT2ASMN1; SMN2TDP1
SCHEMBL4742313 0.80 MEN1 (0.33) MAPTMEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL4742280 0.77 RXRA (0.32) KMT2AALDH1A1TDP1LMNA
SCHEMBL13996806 0.77 KMT2A (0.41) MAPTMEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL14231376 0.77 KMT2A (0.41) MAPTMEN1KMT2AALDH1A1SMN1; SMN2
SCHEMBL4742240 0.76 NPC1 (0.40) MAPTMEN1KMT2AALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8177861-B2 AZO pigment, pigment dispersion containing the AZO pigment, and coloring composition FUJIFILM CORPORATION (JP) 2012-05-15 US disclosed
US-8177861-B2 AZO pigment, pigment dispersion containing the AZO pigment, and coloring composition FUJIFILM CORPORATION (JP) 2012-05-15 US disclosed
US-20110021764-A1 AZO PIGMENT, PIGMENT DISPERSION CONTAINING THE AZO PIGMENT, AND COLORING COMPOSITION FUJIFILM CORPORATION (JP) 2011-01-27 US disclosed
US-20110021764-A1 AZO PIGMENT, PIGMENT DISPERSION CONTAINING THE AZO PIGMENT, AND COLORING COMPOSITION FUJIFILM CORPORATION (JP) 2011-01-27 US disclosed