SCHEMBL4742655

SCHEMBL4742655

CNC(=O)NS(=O)(=O)c1ccc(C)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.63
KMT2A Q03164 1/20 0.61
ALDH1A1 P00352 5/20 0.59
TP53 P04637 2/20 0.59
GAA P10253 2/20 0.59
CA1 P00915 2/20 0.59
CA2 P00918 2/20 0.59
TSHR P16473 2/20 0.59
KDM4E B2RXH2 2/20 0.59
NPSR1 Q6W5P4 1/20 0.59
ALB P02768 1/20 0.59
CYP2C9 P11712 1/20 0.59
TDP1 Q9NUW8 1/20 0.59
CA12 O43570 1/20 0.59
CA4 P22748 1/20 0.59
CA6 P23280 1/20 0.59
CA5A P35218 1/20 0.59
CA7 P43166 1/20 0.59
CA9 Q16790 1/20 0.59
CA13 Q8N1Q1 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5184740 0.90 LMNA (0.69) LMNAKMT2AALDH1A1TP53GAA
SCHEMBL8712446 0.85 ALDH1A1 (0.67) LMNAKMT2AALDH1A1TP53GAA
SCHEMBL9182658 0.83 LMNA (0.76) LMNAKMT2AALDH1A1TP53GAA
SCHEMBL28633918 0.83 CA1 (0.62) LMNAKMT2AALDH1A1TP53GAA
SCHEMBL6394071 0.83 ALDH1A1 (0.64) LMNAALDH1A1CA1CA2TSHR
SCHEMBL19332621 0.83 DHFR (0.68) LMNAKMT2AALDH1A1CA1CA2
SCHEMBL6535038 0.82 LMNA (0.56) LMNAALDH1A1GAACA1CA2
SCHEMBL30716976 0.82 LMNA (0.66) LMNAKMT2AALDH1A1TP53GAA
SCHEMBL692083 0.82 LMNA (0.64) LMNAKMT2AALDH1A1TP53GAA
SCHEMBL9468104 0.82 CA1 (0.64) LMNAKMT2AALDH1A1TP53GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1448397-B1 HEAT-SENSITIVE RECORDING MATERIAL JUJO THERMAL OY (FI) 2007-07-11 EP claimed
US-20050148467-A1 Heat-sensitive recording material JUJO THERMAL OY (FI) 2005-07-07 US claimed
EP-1448397-A1 HEAT-SENSITIVE RECORDING MATERIAL Jujo Thermal Oy (FI) 2004-08-25 EP claimed
WO-2003031194-A1 HEAT-SENSITIVE RECORDING MATERIAL JUJO THERMAL OY (FI) 2003-04-17 WO claimed
EP-0610653-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1997-04-16 EP claimed
EP-0512560-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1996-03-20 EP claimed
EP-0620122-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1996-03-13 EP claimed
EP-0526072-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1995-09-13 EP claimed
US-5446010-A Substrate sheet, thermosensitive colored image forming layer containing colorless dye precursor, binder, color developing agent having sulfonylureido group, aromatic amide sensitizer; storage stability NEW OJI PAPER CO., LTD. (JP) 1995-08-29 US claimed
US-5444036-A Arylsulfonylureido compound, acetoacetanilide compound, sulfonamide derivative; storage stability NEW OIL PAPER CO., LTD. (JP) 1995-08-22 US claimed
EP-0542556-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1995-07-19 EP claimed
EP-0620122-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-10-19 EP claimed
EP-0610653-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-08-17 EP claimed
US-5314859-A Thermosensitive recording material OJI PAPER CO., LTD. (JP) 1994-05-24 US claimed
US-5292711-A Thermosensitive recording material OJI PAPER CO., LTD. (JP) 1994-03-08 US claimed
US-5246906-A Sulfonyl-urea or -thiourea color developer, oil and plasticizer resistant, storage stable OJI PAPER CO., LTD. (JP) 1993-09-21 US claimed
EP-0542556-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1993-05-19 EP claimed
EP-0526072-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1993-02-03 EP claimed
EP-0512560-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1992-11-11 EP claimed
EP-3394056-B1 COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE SHY Therapeutics LLC (US) 2021-04-14 EP disclosed
US-10588894-B2 Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease SHY Therapeutics LLC (US) 2020-03-17 US disclosed
US-20190022074-A1 COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE SHY Therapeutics LLC 2019-01-24 US disclosed
US-20170275513-A1 CURABLE COMPOSITION, CURED PRODUCT, METHOD FOR USING CURABLE COMPOSITION, AND OPTICAL DEVICE LINTEC CORPORATION (JP) 2017-09-28 US disclosed
US-20170253782-A1 CURABLE COMPOSITION, METHOD FOR PRODUCING CURABLE COMPOSITION, CURED OBJECT, METHOD FOR USING CURABLE COMPOSITION, AND OPTICAL DEVICE LINTEC CORPORATION (JP) 2017-09-07 US disclosed
WO-2017140778-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME THE UNIVERSITY OF QUEENSLAND (AU) 2017-08-24 WO disclosed
WO-2017112777-A1 COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE SHY Therapeutics LLC (US) 2017-06-29 WO disclosed
US-20170174699-A1 COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE SHY Therapeutics LLC 2017-06-22 US disclosed
US-8541611-B2 Bifunctional phenyl iso(thio)cyanates, processes and intermediates products for their preparation BASF AKTIENGESELLSCHAFT (DE) 2013-09-24 US disclosed
US-20090048186-A1 Monosaccharide Derivatives as Anti-Inflammatory and/or Anti-Cancer Agents RANBAXY LABORATORIES LIMITED (IN) 2009-02-19 US disclosed
US-20090048186-A1 Monosaccharide Derivatives as Anti-Inflammatory and/or Anti-Cancer Agents RANBAXY LABORATORIES LIMITED (IN) 2009-02-19 US disclosed
WO-2008101810-A1 USE OF UREA DERIVATIVES IN WASHING AND CLEANING COMPOSITIONS HENKEL AG & CO. KGAA (DE) 2008-08-28 WO disclosed
US-7312177-B2 Thermosensitive recording materials OJI PAPER CO., LTD. (JP) 2007-12-25 US disclosed
EP-1448397-B1 HEAT-SENSITIVE RECORDING MATERIAL JUJO THERMAL OY (FI) 2007-07-11 EP disclosed
US-20050255998-A1 Mixture of colour developers CIBA SPECIALTY CHEMICALS CORP. 2005-11-17 US disclosed
US-20050148467-A1 Heat-sensitive recording material JUJO THERMAL OY (FI) 2005-07-07 US disclosed
US-20050106491-A1 Heat sensitive recording material CIBA SPECIALTY CHEMICALS CORP. 2005-05-19 US disclosed
EP-1480836-A1 MIXTURE OF COLOUR DEVELOPERS Ciba SC Holding AG (CH) 2004-12-01 EP disclosed
WO-2003074284-A1 MIXTURE OF COLOUR DEVELOPERS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-09-12 WO disclosed
US-5851951-A Heat sensitive recording material OJI PAPER CO., LTD. (JP) 1998-12-22 US disclosed
EP-0792754-A2 Heat sensitive recording material Oji Paper Co., Ltd. (JP) 1997-09-03 EP disclosed
EP-0610653-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1997-04-16 EP disclosed
EP-0512560-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1996-03-20 EP disclosed
EP-0620122-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1996-03-13 EP disclosed
EP-0526072-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1995-09-13 EP disclosed
US-5446010-A Substrate sheet, thermosensitive colored image forming layer containing colorless dye precursor, binder, color developing agent having sulfonylureido group, aromatic amide sensitizer; storage stability NEW OJI PAPER CO., LTD. (JP) 1995-08-29 US disclosed
US-5444036-A Arylsulfonylureido compound, acetoacetanilide compound, sulfonamide derivative; storage stability NEW OIL PAPER CO., LTD. (JP) 1995-08-22 US disclosed
EP-0620122-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-10-19 EP disclosed
EP-0610653-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-08-17 EP disclosed
US-5292711-A Thermosensitive recording material OJI PAPER CO., LTD. (JP) 1994-03-08 US disclosed
US-5246906-A Sulfonyl-urea or -thiourea color developer, oil and plasticizer resistant, storage stable OJI PAPER CO., LTD. (JP) 1993-09-21 US disclosed
EP-0526072-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1993-02-03 EP disclosed
EP-0512560-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1992-11-11 EP disclosed
EP-0512560-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1992-11-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090048186-A1 Monosaccharide Derivatives as Anti-Inflammatory and/or Anti-Cancer Agents HLA-DRB1, MUC1, ASGR1 LMNA 4860/4885KMT2A 4199/4885ALDH1A1 605/4885
US-10588894-B2 Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease HRAS, KRAS, NRAS LMNA 3109/4885KMT2A 4024/4885ALDH1A1 3448/4885
US-20190022074-A1 COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE HRAS, KRAS, NRAS LMNA 3109/4885KMT2A 4024/4885ALDH1A1 3448/4885
US-20170174699-A1 COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASE MAPK6, MAP3K6, MAPK4 LMNA 3509/4885KMT2A 3544/4885ALDH1A1 2765/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.