Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.52 |
| ▸ | CHKA | P35790 | 9/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CHKB | Q9Y259 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11731502 | 0.98 | CHKA (0.55) | CHKABCHEACHEPABPC1LMNA | |
| Hydrochloric Acid SCHEMBL11637202 | 0.89 | ACHE (0.61) | CHKABCHEACHELMNAKDM4E | |
| SCHEMBL10325407 | 0.86 | ACHE (0.64) | CHKABCHEACHELMNAKDM4E | |
| Bromide SCHEMBL2831425 | 0.84 | ACHE (0.68) | CHKABCHEACHELMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL9488426 | 0.83 | ALDH1A1 (0.56) | CHKALMNAKDM4EALDH1A1RAB9A | |
| Hydrochloric Acid SCHEMBL636283 | 0.81 | LMNA (0.63) | CHKABCHEACHELMNAKDM4E | |
| Hydrochloric Acid SCHEMBL11598831 | 0.79 | LMNA (0.61) | CHKABCHEACHELMNAKDM4E | |
| Hydrochloric Acid SCHEMBL3954504 | 0.79 | CHKA (0.66) | CHKABCHEACHEALDH1A1RAB9A | |
| Hydrochloric Acid SCHEMBL6156150 | 0.79 | CHKA (0.42) | CHKALMNAKDM4EALDH1A1CHKB | |
| SCHEMBL93665 | 0.79 | CHKA (0.59) | CHKABCHEACHELMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080201095-A1 | Method for Calibrating an Analytical Instrument | VERMILLION, INC. | 2008-08-21 | — | — | US | disclosed |
| WO-2008100941-A2 | A METHOD FOR CALIBRATING AN ANALYTICAL INSTRUMENT | CORRELOGIC SYSTEMS INC. (US) | 2008-08-21 | — | — | WO | disclosed |
| US-4310613-A | QUATERNARY AMMONIUM SALT ANTISLUDGING AGENTS | MITSUBISHI PAPER MILLS, LTD. (JP) | 1982-01-12 | — | — | US | disclosed |