Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HK1 | P19367 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7255005 | 0.77 | BRD4 (0.44) | ALDH1A1KDM4ENOS2RXFP1ALOX15 | |
| SCHEMBL30118299 | 0.75 | NOS2 (0.43) | ALDH1A1KDM4ENOS2RXFP1ALOX15 | |
| SCHEMBL8800787 | 0.72 | HSD17B10 (0.44) | ALDH1A1KDM4ERXFP1ALOX15HSD17B10 | |
| Dihydrophenanthridine SCHEMBL2087461 | 0.71 | CA12 (0.56) | KDM4ENOS2ALOX15HSD17B10JAK2 | |
| Dihydrophenanthridine SCHEMBL29791568 | 0.71 | CA12 (0.56) | KDM4ENOS2ALOX15HSD17B10JAK2 | |
| SCHEMBL68595 | 0.71 | CA12 (0.45) | ALDH1A1KDM4ENOS2ALOX15HSD17B10 | |
| SCHEMBL2776950 | 0.71 | NOS2 (0.41) | ALDH1A1KDM4ENOS2RXFP1ALOX15 | |
| SCHEMBL30555345 | 0.71 | NOS2 (0.41) | ALDH1A1KDM4ENOS2RXFP1ALOX15 | |
| SCHEMBL1130729 | 0.71 | NOS2 (0.41) | ALDH1A1KDM4ENOS2RXFP1ALOX15 | |
| Hydrochloric Acid SCHEMBL10863156 | 0.70 | CA12 (0.43) | ALDH1A1KDM4ENOS2ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119841836-B | 5H- [1,2,4] triazinyl [5,6-b ] indole derivatives containing disulfide structure, and preparation method and application thereof | 贵州大学 | 2026-04-07 | — | — | CN | disclosed |
| CN-119841836-A | 5H- [1,2,4] triazinyl [5,6-b ] indole derivatives containing disulfide structure, and preparation method and application thereof | 贵州大学 | 2025-04-18 | — | — | CN | disclosed |
| CN-119841836-A | 5H- [1,2,4] triazinyl [5,6-b ] indole derivatives containing disulfide structure, and preparation method and application thereof | 贵州大学 | 2025-04-18 | — | — | CN | disclosed |
| CN-117865878-A | Chiral indoline-3-one derivative and preparation method thereof | 郑州大学 | 2024-04-12 | — | — | CN | disclosed |
| US-20190241578-A1 | NOVEL COMPOSITIONS USEFUL IN TREATING BRAIN-RELATED DISEASES OR DISORDERS AND METHODS USING SAME | UNIV DREXEL (US) | 2019-08-08 | — | — | US | disclosed |
| US-10287290-B2 | Compositions useful in treating brain-related diseases or disorders and methods using same | DREXEL UNIVERSITY (US) | 2019-05-14 | — | — | US | disclosed |
| US-20170190709-A1 | NOVEL COMPOSITIONS USEFUL IN TREATING BRAIN-RELATED DISEASES OR DISORDERS AND METHODS USING SAME | UNIV DREXEL (US) | 2017-07-06 | — | — | US | disclosed |
| US-9616065-B2 | Compositions useful in treating brain-related diseases or disorders and methods using same | DREXEL UNIVERSITY (US) | 2017-04-11 | — | — | US | disclosed |
| US-20160074408-A1 | NOVEL COMPOSITIONS USEFUL IN TREATING BRAIN-RELATED DISEASES OR DISORDERS AND METHODS USING SAME | DREXEL UNIVERSITY (US) | 2016-03-17 | — | — | US | disclosed |
| WO-2014172453-A2 | NOVEL COMPOSITIONS USEFUL IN TREATING BRAIN-RELATED DISEASES OR DISORDERS AND METHODS USING SAME | PHILADELPHIA HEALTH AND EDUCATION CORPORATION D/B/A DREXEL UNIVERSITY COLLEGE OF MEDICINE (US) | 2014-10-23 | — | — | WO | disclosed |
| WO-2008101824-A1 | IMIDAZO[1',5':1,6] PYRIDO[3,4-B]INDOLES DERIVATIVES AND THERAPEUTICAL USE THEREOF | FOURTILLAN (FR) | 2008-08-28 | — | — | WO | disclosed |
| EP-1509501-B1 | 1-(AMINOALKYL)-3-SULFONYLINDOLE AND -INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH CORP (US) | 2006-12-20 | — | — | EP | disclosed |
| US-6727246-B2 | ENHANCEMENT OF COGNITION AND MEMORY IN HUMAN DISEASES SUCH AS ALZHEIMER'S | WYETH | 2004-04-27 | — | — | US | disclosed |
| US-20030232828-A1 | 1-(AMINOALKYL)-3-SULFONYLINDOLE AND-INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH | 2003-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190241578-A1 | NOVEL COMPOSITIONS USEFUL IN TREATING BRAIN-RELATED DISEASES OR DISORDERS AND METHODS USING SAME | SLC18A2, SLC6A2, SLC1A2 | ALDH1A1 1315/4885KDM4E 3171/4885NOS2 812/4885 |
| US-20170190709-A1 | NOVEL COMPOSITIONS USEFUL IN TREATING BRAIN-RELATED DISEASES OR DISORDERS AND METHODS USING SAME | SLC18A2, SLC6A2, SLC1A2 | ALDH1A1 1315/4885KDM4E 3171/4885NOS2 812/4885 |
| US-20030232828-A1 | 1-(AMINOALKYL)-3-SULFONYLINDOLE AND-INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | HTR6, HTR3A, HTR5A | ALDH1A1 633/4885KDM4E 4095/4885NOS2 1697/4885 |
| US-10287290-B2 | Compositions useful in treating brain-related diseases or disorders and methods using same | SLC18A2, SLC6A2, SLC1A2 | ALDH1A1 1170/4885KDM4E 2767/4885NOS2 546/4885 |
| US-20160074408-A1 | NOVEL COMPOSITIONS USEFUL IN TREATING BRAIN-RELATED DISEASES OR DISORDERS AND METHODS USING SAME | SLC18A2, SLC18A3, SLC1A2 | ALDH1A1 1380/4885KDM4E 3235/4885NOS2 673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.