SCHEMBL4744554

SCHEMBL4744554

[SiH3]C(OCC1CO1)C1CO1

nearest known ligand 0.38

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.38
ALDH1A1 P00352 6/20 0.37
MAPK1 P28482 1/20 0.34
SMN1; SMN2 Q16637 2/20 0.33
TDP1 Q9NUW8 2/20 0.32
TP53 P04637 2/20 0.31
CYP3A4 P08684 2/20 0.31
HIF1A Q16665 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23175183 0.74
SCHEMBL3645580 0.73 TSHR (0.38) TSHRALDH1A1MAPK1SMN1; SMN2TDP1
SCHEMBL8950934 0.73 TSHR (0.38) TSHRALDH1A1MAPK1SMN1; SMN2TDP1
SCHEMBL2390211 0.73 TSHR (0.38) TSHRALDH1A1MAPK1SMN1; SMN2TDP1
SCHEMBL9515799 0.73 TSHR (0.38) TSHRALDH1A1MAPK1SMN1; SMN2TDP1
SCHEMBL30179645 0.73 TSHR (0.39) TSHRALDH1A1MAPK1SMN1; SMN2TDP1
SCHEMBL8458392 0.71
SCHEMBL177653 0.71
SCHEMBL37335 0.70 ALDH1A1 (0.44) TSHRALDH1A1MAPK1SMN1; SMN2TDP1
SCHEMBL465368 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008098213-A9 PURE POLYUREA AND METHOD FOR MAKING SAME REACTAMINE TECHNOLOGY LLC (US) 2008-12-24 WO disclosed
WO-2008098213-A2 PURE POLYUREA AND METHOD FOR MAKING SAME REACTAMINE TECHNOLOGY, LLC (US) 2008-08-14 WO disclosed
WO-2008086343-A2 SILICONE MODIFIED POLYUREA REACTAMINE TECHNOLOGY, LLC (US) 2008-07-17 WO disclosed
US-7348392-B2 Polyol prepolymers and amines with epoxy group for silicone resins REACTAMINE TECHNOLOGY, LLC (US) 2008-03-25 US disclosed
US-20080008866-A1 Silicone modified polyurea REACTAMINE TECHNOLOGY, LLC 2008-01-10 US disclosed
US-20070270240-A1 Pure polyurea and method for making same REACTAMINE TECHNOLOGY, LLC 2007-11-22 US disclosed
EP-1593699-B1 Silicone modified acrylics and epoxies REACTAMINE TECHNOLOGY LLC (US) 2007-10-10 EP disclosed
US-7250482-B2 Silicone modified acrylics and epoxies REACTAMINE TECHNOLOGY, LLC (US) 2007-07-31 US disclosed
US-7247351-B2 Silicone modified polyurea REACTAMINE TECHNOLOGY, LLC (US) 2007-07-24 US disclosed
US-7238767-B2 Silicone modified polyurea REACTAMINE TECHNOLOGY, LLC (US) 2007-07-03 US disclosed
US-20060189778-A1 Silicone modified polyurea REACTAMINE TECHNOLOGY, LLC (US) 2006-08-24 US disclosed
US-20060084767-A1 Silicone modified acrylics and epoxies REACTAMINE TECHNOLOGY, LLC (US) 2006-04-20 US disclosed
US-20060047090-A1 Silicone modified polyurea REACTAMINE TECHNOLOGY, LLC (US) 2006-03-02 US disclosed
US-20060047091-A1 Silicone modified acrylics and epoxies REACTAMINE TECHNOLOGY, LLC (US) 2006-03-02 US disclosed
US-20060035031-A1 Silicone modified polyurea REACTAMINE TECHNOLOGY, LLC (US) 2006-02-16 US disclosed
EP-1593699-A1 Silicone modified acrylics and epoxies Reactamine Technology, LLC (US) 2005-11-09 EP disclosed
EP-1537157-A1 SILICONE MODIFIED POLYUREA Reactamine Technology, LLC (US) 2005-06-08 EP disclosed
US-20040210010-A1 Silicone modified acrylics and epoxies REACTAMINE TECHNOLOGY, LLC 2004-10-21 US disclosed
WO-2004022619-A1 SILICONE MODIFIED POLYUREA REACTAMINE TECHNOLOGY, LLC (US) 2004-03-18 WO disclosed
US-20040054112-A1 Silicone modified polyurea REACTAMINE TECHNOLOGY, LLC 2004-03-18 US disclosed