Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14069149 | 0.85 | BRD4 (0.46) | PRMT5WDR77PAK1CYP11B1CYP11B2 | |
| SCHEMBL2373579 | 0.70 | RORC (0.40) | CYP11B1CYP11B2GPR119NPC1ALDH1A1 | |
| SCHEMBL2373819 | 0.69 | ABHD6 (0.59) | GPR119NPC1RAB9ASMN1; SMN2GFER | |
| SCHEMBL4747825 | 0.68 | PRMT5 (0.49) | PRMT5WDR77CYP11B1CYP11B2AAK1 | |
| SCHEMBL2373645 | 0.67 | RIPK1 (0.68) | — | |
| SCHEMBL4746507 | 0.66 | DYRK1A (0.56) | PRMT5WDR77AAK1 | |
| SCHEMBL4200987 | 0.66 | MAPK8 (0.60) | PRMT5WDR77AAK1MAP3K12 | |
| SCHEMBL4743697 | 0.66 | PRMT5 (0.53) | PRMT5WDR77AAK1 | |
| SCHEMBL2778816 | 0.66 | NPC1 (0.64) | PRMT5WDR77NPC1ALDH1A1MAPT | |
| SCHEMBL4747758 | 0.66 | PRMT5 (0.55) | PRMT5WDR77AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | claimed |
| WO-2008110508-A1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH INAPPROPRIATE IKK1 ACTIVITY | GLAXO GROUP LIMITED (GB) | 2008-09-18 | — | — | WO | disclosed |