Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | EIF2AK3 | Q9NZJ5 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL869258 | 0.83 | BRD4 (0.47) | RORCCYP11B1CYP11B2USP30NPC1 | |
| SCHEMBL2374644 | 0.75 | KDR (0.43) | CYP11B1CYP11B2EIF2AK3RIPK1 | |
| SCHEMBL2373984 | 0.73 | NOTUM (0.60) | SCN9ASCN10ANPC1RAB9AL3MBTL1 | |
| SCHEMBL2373819 | 0.73 | ABHD6 (0.59) | HTR2ANPC1RAB9AL3MBTL1GPR119 | |
| SCHEMBL2778816 | 0.72 | NPC1 (0.64) | NPC1RAB9AL3MBTL1ALDH1A1MAPT | |
| SCHEMBL4745700 | 0.70 | PRMT5 (0.43) | CYP11B1CYP11B2NPC1RAB9AGPR119 | |
| SCHEMBL5269117 | 0.69 | GPR119 (0.41) | NPC1RAB9AL3MBTL1GPR119ALDH1A1 | |
| SCHEMBL2375097 | 0.69 | EIF2AK3 (0.65) | NPC1RAB9AEIF2AK3ALDH1A1MAPT | |
| SCHEMBL2373042 | 0.67 | EIF2AK3 (0.43) | NPC1RAB9AGPR119EIF2AK3ALDH1A1 | |
| SCHEMBL2373645 | 0.67 | RIPK1 (0.68) | EIF2AK3RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |