Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.53 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | IDH1 | O75874 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31046593 | 1.00 | EGFR (0.61) | EGFRALDH1A1HSD17B10CYP1A2RAB9A | |
| Acetonitrile SCHEMBL28273231 | 0.94 | EGFR (0.59) | EGFRALDH1A1HSD17B10CYP1A2RAB9A | |
| SCHEMBL11238391 | 0.91 | EGFR (0.54) | EGFRALDH1A1HSD17B10CYP1A2RAB9A | |
| SCHEMBL4749975 | 0.85 | MEN1 (0.60) | EGFRALDH1A1HSD17B10RAB9AMEN1 | |
| SCHEMBL1040883 | 0.84 | ALDH1A1 (0.59) | ALDH1A1HSD17B10CYP1A2RAB9AMEN1 | |
| SCHEMBL1025225 | 0.84 | MEN1 (0.56) | EGFRALDH1A1RAB9AMEN1NPC1 | |
| SCHEMBL12049693 | 0.83 | IDH1 (0.54) | EGFRALDH1A1HSD17B10RAB9AMEN1 | |
| SCHEMBL171190 | 0.82 | ALDH1A1 (0.66) | ALDH1A1HSD17B10CYP1A2RAB9AMEN1 | |
| SCHEMBL21715154 | 0.82 | GRM5 (0.58) | ALDH1A1HSD17B10CYP1A2RAB9AMEN1 | |
| SCHEMBL30368222 | 0.82 | ALDH1A1 (0.66) | ALDH1A1HSD17B10CYP1A2RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 164 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109265325-A | A kind of bis- bromo alkenes compounds of 1,2- and its preparation method and application | 广东工业大学 | 2019-01-25 | — | — | CN | claimed |
| CN-112176418-B | High-throughput compound library construction and screening method and reaction device | 中宏鑫投资控股(深圳)有限公司 | 2024-11-29 | — | — | CN | disclosed |
| CN-114057658-B | Polytriazole compound, and preparation method and application thereof | 中宏鑫投资控股(深圳)有限公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-112292386-B | Tetrahydropyrane-based thiodisaccharide mimetics as galectin-3 inhibitors | 百时美施贵宝公司 | 2024-06-11 | — | — | CN | disclosed |
| US-11970511-B2 | Tetrahydropyran-based thiodisaccharide mimics as Galectin-3 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-04-30 | — | — | US | disclosed |
| CN-116903585-A | Oxo-pyridine derivative and application thereof in medicine | 天津药物研究院有限公司 | 2023-10-20 | — | — | CN | disclosed |
| CN-110590485-B | FSO 2 N 3 Use in the production of azido compounds | 中宏鑫投资控股(深圳)有限公司 | 2023-04-14 | — | — | CN | disclosed |
| US-20220356182-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | MERCK SHARP & DOHME CORP. (US) | 2022-11-10 | — | — | US | disclosed |
| US-20220356182-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | MERCK SHARP & DOHME CORP. (US) | 2022-11-10 | — | — | US | disclosed |
| US-20220291202-A1 | HIGH THROUGHPUT METHOD FOR CONSTRUCTING AND SCREENING COMPOUND LIBRARY AND REACTION DEVICE | DEEPSYN. CO (CN) | 2022-09-15 | — | — | US | disclosed |
| EP-1274424-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-15 | — | — | EP | disclosed |
| US-20020128263-A1 | Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles | F.HOFFMANN-LA ROCHE AG (CH) | 2002-09-12 | — | — | US | disclosed |
| WO-2002046166-A1 | PHENYLETHENYL OR PHENYLETHINYL DERIVATIVES AS GLUTAMATE RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-13 | — | — | WO | disclosed |
| WO-2001078723-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-10-25 | — | — | WO | disclosed |
| EP-0834499-B1 | Process for the preparation of aromatic vinyl compounds | DAINIPPON INK & CHEMICALS (JP) | 2001-07-25 | — | — | EP | disclosed |
| EP-0834499-A1 | Process for the preparation of aromatic vinyl compounds | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1998-04-08 | — | — | EP | disclosed |
| EP-0171209-B1 | ACETYLENIC PHENOXYPROPANOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION | McNeilab, Inc. (US) | 1989-03-01 | — | — | EP | disclosed |
| US-4652584-A | Acetylenic phenoxypropanol derivatives and pharmaceutical compositions for the treatment of hypertension | MCNEILAB, INC. (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0171209-A1 | Acetylenic phenoxypropanol derivatives and pharmaceutical compositions for the treatment of hypertension | McNeilab, Inc. (US) | 1986-02-12 | — | — | EP | disclosed |
| US-4162265-A | Aromatic enyne compounds and their synthesis | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) | 1979-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11970511-B2 | Tetrahydropyran-based thiodisaccharide mimics as Galectin-3 inhibitors | LGALS3, LGALS1, LGALS3BP | EGFR 2203/4885ALDH1A1 2364/4885HSD17B10 2921/4885 |
| US-20220356182-A1 | INHIBITORS OF HEPATITIS C VIRUS REPLICATION | HAVCR2, HCCS, EIF2AK2 | EGFR 3021/4885ALDH1A1 2400/4885HSD17B10 1056/4885 |
| US-20020128263-A1 | Phenylethynyl and styryl derivatives of imidazole and fused ring heterocycles | GRM5, GRIK5, GRM1 | EGFR 401/4885ALDH1A1 2819/4885HSD17B10 1746/4885 |
| US-20220291202-A1 | HIGH THROUGHPUT METHOD FOR CONSTRUCTING AND SCREENING COMPOUND LIBRARY AND REACTION DEVICE | CMA1, DHX29, DHX15 | EGFR 3317/4885ALDH1A1 1746/4885HSD17B10 358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.