Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2804478 | 0.82 | ALOX15 (0.43) | ALDH1A1MAPK1SMN1; SMN2ALOX15TSHR | |
| SCHEMBL29415461 | 0.82 | ALOX15 (0.43) | ALDH1A1MAPK1SMN1; SMN2ALOX15TSHR | |
| SCHEMBL11375028 | 0.82 | IGFBP3 (0.49) | ALDH1A1MAPK1SMN1; SMN2ALOX15TSHR | |
| SCHEMBL31125623 | 0.81 | ALDH1A1 (0.68) | ALDH1A1MAPK1SMN1; SMN2CYP3A4ACHE | |
| SCHEMBL5391695 | 0.81 | ALDH1A1 (0.52) | ALDH1A1MAPK1SMN1; SMN2ALOX15CYP3A4 | |
| SCHEMBL7788152 | 0.81 | ALDH1A1 (0.68) | ALDH1A1MAPK1SMN1; SMN2CYP3A4ACHE | |
| SCHEMBL12641092 | 0.81 | ALOX15 (0.46) | ALDH1A1MAPK1SMN1; SMN2ALOX15TSHR | |
| SCHEMBL22445800 | 0.79 | ALDH1A1 (0.50) | ALDH1A1MAPK1SMN1; SMN2ALOX15CYP3A4 | |
| SCHEMBL4073122 | 0.78 | ALDH1A1 (0.39) | ALDH1A1MAPK1SMN1; SMN2CYP3A4ACHE | |
| SCHEMBL24665086 | 0.78 | RXFP1 (0.44) | ALDH1A1MAPK1SMN1; SMN2ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008109343-A1 | METHODS OF TREATING BIPOLAR DISORDER AND MEMORY AND/OR COGNITIVE IMPAIRMENT ASSOCIATED THEREWITH WITH (+)-ISOPROPYL 2-METHOXYETHYL 4-(2-CHLORO-3-CYANO-PHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-PYRIDINE-3,5-DICARBOXYLATE | MEMORY PHARMACEUTICALS CORPORATION (US) | 2008-09-12 | — | — | WO | claimed |
| EP-0245918-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES | GLAXO S.p.A. (IT) | 1993-05-05 | — | — | EP | disclosed |