Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.33 |
| ▸ | MAT2A | P31153 | 2/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4750217 | 0.99 | PDE2A (0.37) | PDE2AGRM2SRCADORA1MAT2A | |
| SCHEMBL4747767 | 0.95 | GRM2 (0.37) | PDE2AGRM2SRCHTR1ADRD2 | |
| SCHEMBL4750004 | 0.78 | GRM2 (0.39) | GRM2ALDH1A1 | |
| SCHEMBL4750623 | 0.77 | GRM2 (0.40) | GRM2HTR1ADRD2HTR2AALDH1A1 | |
| SCHEMBL4747299 | 0.75 | GRM2 (0.38) | GRM2ALDH1A1 | |
| SCHEMBL4747263 | 0.73 | GRM2 (0.36) | GRM2ALDH1A1 | |
| SCHEMBL5815996 | 0.69 | ALDH1A1 (0.37) | GRM2ADORA1ALDH1A1ADORA2A | |
| SCHEMBL4750023 | 0.68 | HSF1 (0.41) | GRM2ADORA1MAT2AALDH1A1POLB | |
| SCHEMBL10232910 | 0.67 | KDM4E (0.41) | GRM2HTR2AALDH1A1 | |
| SCHEMBL4788109 | 0.67 | MAPK9 (0.44) | ADORA1ALDH1A1POLBADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123755-A1 | A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA | SK CHEMICALS CO., LTD. (KR) | 2008-10-16 | — | — | WO | claimed |
| WO-2008123755-A1 | A PHARMACEUTICAL COMPOSITIONS CONTAINING LACTAM TYPE PYRIDINE DERIVATIVES AS AN EFFECTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF ISCHEMIA | SK CHEMICALS CO., LTD. (KR) | 2008-10-16 | — | — | WO | disclosed |