Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4748143 | 1.00 | HCAR2 (0.36) | HCAR2KEAP1NFE2L2BACE1BTN3A1 | |
| SCHEMBL1877801 | 0.79 | ALDH1A1 (0.33) | HCAR2KEAP1NFE2L2 | |
| SCHEMBL15791063 | 0.76 | HCAR2 (0.40) | HCAR2KEAP1NFE2L2 | |
| SCHEMBL17048413 | 0.74 | HCAR2 (0.36) | HCAR2KEAP1NFE2L2 | |
| SCHEMBL20981993 | 0.74 | HCAR2 (0.36) | HCAR2KEAP1NFE2L2 | |
| SCHEMBL17048269 | 0.74 | HCAR2 (0.36) | HCAR2KEAP1NFE2L2 | |
| SCHEMBL17048371 | 0.74 | HCAR2 (0.36) | HCAR2KEAP1NFE2L2 | |
| SCHEMBL8917913 | 0.74 | CTSL (0.40) | BACE1BTN3A1 | |
| SCHEMBL8917915 | 0.74 | CTSL (0.40) | BACE1BTN3A1 | |
| SCHEMBL12147875 | 0.73 | HCAR2 (0.41) | HCAR2KEAP1NFE2L2BACE1BTN3A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140142096-A1 | Fused Substituted Aminopyrrolidine Derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-05-22 | — | — | US | disclosed |
| US-20140142096-A1 | Fused Substituted Aminopyrrolidine Derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-05-22 | — | — | US | disclosed |
| EP-2097400-B1 | FUSED SUBSTITUTED AMINOPYRROLIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2013-07-03 | — | — | EP | disclosed |
| US-20130029977-A9 | Fused substituted aminopyrrolidine derivative | DAIICHI SANKYO COMPANY, LIMITED | 2013-01-31 | — | — | US | disclosed |
| US-20120108582-A1 | Fused substituted aminopyrrolidine derivative | DAIICHI SANKYO COMPANY, LIMITED | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108582-A1 | Fused substituted aminopyrrolidine derivative | NQO2, QDPR, IL4I1 | HCAR2 2296/4885KEAP1 867/4885NFE2L2 1974/4885 |
| US-20140142096-A1 | Fused Substituted Aminopyrrolidine Derivative | NQO2, QDPR, IL4I1 | HCAR2 2296/4885KEAP1 867/4885NFE2L2 1974/4885 |
| US-20130029977-A9 | Fused substituted aminopyrrolidine derivative | NQO2, QDPR, IL4I1 | HCAR2 2296/4885KEAP1 867/4885NFE2L2 1974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.