SCHEMBL28034516

SCHEMBL28034516

N#Cc1c[nH]c(C(F)(F)F)c1-c1cc(Cl)cc(Cl)c1Cl

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
AR P10275 2/20 0.33
DYRK1A Q13627 1/20 0.32
LRRK2 Q5S007 1/20 0.31
ALDH1A1 P00352 1/20 0.31
PSD A5PKW4 1/20 0.30
MCL1 Q07820 1/20 0.30
GPR35 Q9HC97 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28035135 0.80 DYRK1A (0.35) ARDYRK1ALRRK2
SCHEMBL28034518 0.79 KDM4E (0.36) ARDYRK1ALRRK2ALDH1A1PSD
SCHEMBL9023027 0.78 MCL1 (0.44) ARDYRK1ALRRK2ALDH1A1PSD
SCHEMBL4748506 0.74 DYRK1A (0.37) ARDYRK1ALRRK2MCL1
SCHEMBL28035243 0.71 CHUK (0.44) ARLRRK2
SCHEMBL28035241 0.70 CHUK (0.42) ARALDH1A1
SCHEMBL1179642 0.69 KDM4E (0.33) ALDH1A1
SCHEMBL9336043 0.65 DYRK1A (0.39) DYRK1ALRRK2ALDH1A1MCL1GPR35
SCHEMBL3077861 0.64 ALDH1A1 (0.52) ALDH1A1GPR35
SCHEMBL18405902 0.62 LRRK2 (0.44) DYRK1ALRRK2MCL1GPR35

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104982435-A Biocide composition comprising pyrithione and pyrrole derivatives ARCH CHEM INC 2015-10-21 CN disclosed