Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 8/20 | 0.46 |
| ▸ | ACHE | P22303 | 8/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.38 |
| ▸ | ITGAV | P06756 | 2/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787772 | 0.90 | POLB (0.41) | MAOAMAOBNISCHITGB3ITGAV | |
| SCHEMBL4787684 | 0.90 | GAA (0.40) | MAOAMAOBNISCH | |
| SCHEMBL4787520 | 0.82 | HTR1B (0.46) | WDR5MAOAMAOBNISCHITGB3 | |
| SCHEMBL14042569 | 0.82 | HTR1B (0.46) | WDR5MAOAMAOBNISCHITGB3 | |
| SCHEMBL4749208 | 0.81 | FFAR1 (0.38) | WDR5MAOB | |
| SCHEMBL949042 | 0.81 | KDM4E (0.52) | MAOAMAOBNISCH | |
| Iodide SCHEMBL951481 | 0.80 | KDM4E (0.51) | MAOAMAOBNISCH | |
| Acetic Acid SCHEMBL4787678 | 0.80 | MAOA (0.42) | MAOAMAOBNISCHITGB3ITGAV | |
| Acetic Acid SCHEMBL4787766 | 0.80 | OPRM1 (0.41) | MAOAMAOBNISCH | |
| SCHEMBL4114349 | 0.79 | WDR5 (0.48) | WDR5MAOAMAOBNISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123821-A1 | 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS | ALBIREO AB (SE) | 2008-10-16 | — | — | WO | disclosed |