Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749432 | 0.87 | CYP2D6 (0.34) | MEN1KMT2ATAAR1CYP2D6HCRTR1 | |
| SCHEMBL4026176 | 0.84 | KMT2A (0.39) | MEN1KMT2ATAAR1CYP2D6MAPK1 | |
| SCHEMBL4752824 | 0.84 | TAAR1 (0.34) | TAAR1CYP2D6HCRTR1HCRTR2RIPK1 | |
| SCHEMBL4749426 | 0.83 | EED (0.42) | TAAR1CYP2D6RIPK1 | |
| SCHEMBL4749424 | 0.83 | EED (0.42) | TAAR1CYP2D6RIPK1 | |
| SCHEMBL4749201 | 0.82 | MEN1 (0.44) | MEN1KMT2ATAAR1CYP2D6MAPK1 | |
| SCHEMBL4748993 | 0.82 | MEN1 (0.44) | MEN1KMT2ATAAR1CYP2D6MAPK1 | |
| SCHEMBL4749407 | 0.75 | EED (0.32) | MEN1KMT2ARIPK1 | |
| SCHEMBL4752869 | 0.74 | MEN1 (0.40) | MEN1KMT2AMAPK1 | |
| SCHEMBL4751351 | 0.74 | MEN1 (0.40) | MEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | claimed |
| WO-2008140810-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2008-11-20 | — | — | WO | disclosed |