Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4744528 | 0.83 | LMNA (0.52) | LMNAMAPTPOLBKMT2ANR4A2 | |
| SCHEMBL7047331 | 0.81 | CYP3A4 (0.40) | CYP3A4MAPK1HSP90AA1KDM4EALDH1A1 | |
| SCHEMBL4788222 | 0.79 | PARP1 (0.46) | LMNAMAPTKMT2AHSP90AA1NR4A2 | |
| SCHEMBL9380176 | 0.73 | NQO2 (0.48) | KDM4E | |
| SCHEMBL28842256 | 0.73 | POLB (0.41) | LMNAMAPTCYP3A4POLBKMT2A | |
| SCHEMBL25380852 | 0.72 | CYP3A4 (0.37) | MAPTCYP3A4MAPK1KDM4EALDH1A1 | |
| SCHEMBL31353274 | 0.71 | PDE3B (0.35) | LMNAMAPTPOLBKMT2APDE3B | |
| SCHEMBL2823571 | 0.71 | ALDH1A1 (0.33) | MAPTCYP3A4MAPK1POLBKMT2A | |
| SCHEMBL11100714 | 0.70 | MAPT (0.49) | LMNAMAPTMAPK1KMT2AKDM4E | |
| SCHEMBL4748554 | 0.69 | POLB (0.53) | LMNAPOLBKMT2ANR4A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008117079-A1 | ANTIMICROBIAL COMPOUNDS BASED UPON 4-AMINOQUINOLINE | HELPERBY THERAPEUTICS LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |