Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | ACP3 | P15309 | 3/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970288 | 0.89 | ACP3 (0.50) | CES2ACP3PNMTIDO1TDO2 | |
| SCHEMBL5185325 | 0.87 | ACP3 (0.54) | CES2ACP3PNMTLMNAIDO1 | |
| SCHEMBL17593410 | 0.86 | CES2 (0.47) | CES2ACP3PNMTLMNAGAA | |
| SCHEMBL7555691 | 0.82 | CES2 (0.46) | CES2ACP3PNMTIDO1TDO2 | |
| SCHEMBL3905843 | 0.81 | CES2 (0.44) | CES2ACP3PNMTIDO1TDO2 | |
| SCHEMBL11050404 | 0.81 | MAOB (0.47) | CES2ACP3LMNAGAAIDO1 | |
| SCHEMBL5990120 | 0.81 | CES2 (0.43) | CES2ACP3PNMTIDO1TDO2 | |
| SCHEMBL7861158 | 0.80 | HDAC4 (0.42) | CES2IDO1TDO2SLC6A4MAPT | |
| SCHEMBL9602349 | 0.77 | KIF11 (0.48) | CES2ACP3PNMTGAAMEN1 | |
| SCHEMBL1515746 | 0.76 | HTR2A (0.50) | LMNASLC6A4MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123821-A1 | 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS | ALBIREO AB (SE) | 2008-10-16 | — | — | WO | disclosed |