Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NAAA | Q02083 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA3 | P07451 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749719 | 0.88 | SMN1; SMN2 (0.48) | SMN1; SMN2NAAACA2GAAMAPT | |
| SCHEMBL3349870 | 0.81 | HDAC2 (0.51) | SMN1; SMN2GAAKDM4EALDH1A1LMNA | |
| SCHEMBL17373956 | 0.77 | NAAA (0.68) | SMN1; SMN2NAAACA2L3MBTL1 | |
| SCHEMBL17373856 | 0.77 | NAAA (0.68) | SMN1; SMN2NAAACA2L3MBTL1 | |
| SCHEMBL4750119 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2NAAACA2MAPTTSHR | |
| SCHEMBL2914113 | 0.77 | SMN1; SMN2 (0.79) | SMN1; SMN2NAAATSHRALDH1A1HPGD | |
| SCHEMBL165561 | 0.75 | ALDH1A1 (0.46) | SMN1; SMN2CA2GAAMAPTKDM4E | |
| SCHEMBL3863167 | 0.74 | MEN1 (0.37) | SMN1; SMN2CA2CA12CA9HCAR3 | |
| SCHEMBL5158285 | 0.74 | HCAR3 (0.50) | SMN1; SMN2CA2GAAMAPTTSHR | |
| SCHEMBL20991401 | 0.74 | SMN1; SMN2 (0.73) | SMN1; SMN2NAAATSHRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119772-A1 | AMIDE DERIVATIVES AS INHIBITORS OF ASPARTYL PROTEASES | MEDIVIR AB (SE) | 2008-10-09 | — | — | WO | disclosed |