Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4746893 | 1.00 | ALDH1A1 (0.47) | ALDH1A1HPGDSMN1; SMN2POLBKDM4E | |
| SCHEMBL4749742 | 0.99 | ALDH1A1 (0.46) | ALDH1A1HPGDSMN1; SMN2POLBKDM4E | |
| SCHEMBL4750442 | 0.89 | CNR1 (0.47) | ALDH1A1HPGDKDM4EMAPTTSHR | |
| SCHEMBL5761600 | 0.80 | PARP1 (0.43) | — | |
| SCHEMBL8823728 | 0.76 | DRD2 (0.40) | — | |
| SCHEMBL5764199 | 0.76 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4EL3MBTL1HTT | |
| SCHEMBL8823733 | 0.76 | DRD2 (0.40) | — | |
| SCHEMBL10699275 | 0.70 | DRD2 (0.33) | — | |
| SCHEMBL30601522 | 0.70 | DRD2 (0.45) | — | |
| SCHEMBL875341 | 0.70 | DRD2 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |