Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30601522 | 1.00 | DRD2 (0.45) | DRD2DRD3DPP4DYRK1ANISCH | |
| SCHEMBL9392163 | 1.00 | DRD2 (0.45) | DRD2DRD3DPP4DYRK1ANISCH | |
| SCHEMBL21585684 | 0.80 | DPP4 (0.39) | DRD2DRD3DPP4DYRK1AALOX15B | |
| SCHEMBL9900909 | 0.79 | MAOA (0.40) | DRD2DRD3DPP4MAOA | |
| SCHEMBL23652957 | 0.79 | AADAT (0.37) | DPP4 | |
| SCHEMBL19054489 | 0.79 | HTR7 (0.38) | DRD2 | |
| SCHEMBL10699275 | 0.79 | DRD2 (0.33) | DRD2 | |
| Hydrochloric Acid SCHEMBL21810859 | 0.77 | HTR2A (0.34) | DRD2 | |
| SCHEMBL5761600 | 0.77 | PARP1 (0.43) | DRD2 | |
| SCHEMBL8854697 | 0.76 | MEN1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012039657-A1 | NOVEL CHROMANE COMPOUND FOR THE TREATMENT OF PAIN DISORDERS | ASTRAZENECA AB (SE) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012039657-A1 | NOVEL CHROMANE COMPOUND FOR THE TREATMENT OF PAIN DISORDERS | ASTRAZENECA AB (SE) | 2012-03-29 | — | — | WO | disclosed |