Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8823728 | 1.00 | DRD2 (0.40) | DRD2 | |
| SCHEMBL5764199 | 0.83 | ALDH1A1 (0.46) | DRD2 | |
| SCHEMBL5761600 | 0.82 | PARP1 (0.43) | DRD2 | |
| SCHEMBL8823727 | 0.77 | DRD2 (0.43) | DRD2 | |
| SCHEMBL8447239 | 0.76 | DRD2 (0.58) | DRD2 | |
| SCHEMBL4750426 | 0.76 | ALDH1A1 (0.47) | — | |
| SCHEMBL5760572 | 0.76 | HTR1A (0.47) | — | |
| SCHEMBL4746893 | 0.76 | ALDH1A1 (0.47) | — | |
| SCHEMBL841567 | 0.76 | SCN9A (0.48) | — | |
| SCHEMBL4750442 | 0.76 | CNR1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641807-A | Method for the treatment of depression | ASTRA AKTIEBOLAG (SE) | 1997-06-24 | — | — | US | disclosed |
| US-5639772-A | Chroman derivatives | ASTRA AKTIEBOLAG (SE) | 1997-06-17 | — | — | US | disclosed |
| US-5500425-A | Chroman derivatives and a method of treating 5-HT mediated disorders | AKTIEBOLAGET ASTRA (SE) | 1996-03-19 | — | — | US | disclosed |