Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.30 |
| ▸ | WNT3A | P56704 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4982728 | 0.90 | P2RX7 (0.32) | SLC6A2SLC6A4SLC6A3P2RX7HTT | |
| SCHEMBL5707632 | 0.90 | P2RX7 (0.32) | SLC6A2SLC6A4SLC6A3P2RX7HTT | |
| SCHEMBL5707571 | 0.90 | P2RX7 (0.32) | SLC6A2SLC6A4SLC6A3P2RX7HTT | |
| SCHEMBL3395341 | 0.86 | HTT (0.33) | SLC6A2SLC6A4SLC6A3P2RX7HTT | |
| SCHEMBL6842407 | 0.85 | SLC6A2 (0.33) | SLC6A2SLC6A4SLC6A3P2RX7HTT | |
| SCHEMBL2907033 | 0.85 | SLC6A2 (0.33) | SLC6A2SLC6A4SLC6A3P2RX7HTT | |
| SCHEMBL5707587 | 0.85 | SLC6A2 (0.33) | SLC6A2SLC6A4SLC6A3P2RX7HTT | |
| SCHEMBL8960840 | 0.85 | SLC6A2 (0.33) | SLC6A2SLC6A4SLC6A3P2RX7HTT | |
| SCHEMBL6844452 | 0.80 | ALDH1A1 (0.39) | HTTALDH1A1 | |
| SCHEMBL4411815 | 0.79 | CTNNB1 (0.32) | P2RX7HTTCTNNB1WNT3AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147454-A1 | SELECTIVE INHIBITORS OF TRANSLESION DNA REPLICATION | CASE WESTERN RESERVE UNIVERSITY (US) | 2008-12-04 | — | — | WO | disclosed |
| WO-2006101911-A1 | SELECTIVE INHIBITORS OF TRANSLESION DNA REPLICATION | CASE WESTERN RESERVE UNIVERSITY (US) | 2006-09-28 | — | — | WO | disclosed |