Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4370301 | 0.94 | MEP1B (0.37) | CYP3A4MEP1BCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL2342519 | 0.89 | CYP3A4 (0.34) | CYP3A4ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL13492096 | 0.88 | CYP3A4 (0.33) | CYP3A4MEP1BCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL1343942 | 0.87 | CYP3A4 (0.47) | CYP3A4MEP1BCYP2C9CYP2C19GPR35 | |
| SCHEMBL2340956 | 0.86 | MEN1 (0.37) | ALDH1A1MEN1KMT2AL3MBTL1KDM4E | |
| SCHEMBL4754754 | 0.85 | CAMK2A (0.41) | CYP3A4MEP1BCYP2C9CYP2C19THRB | |
| SCHEMBL13481896 | 0.85 | CYP3A4 (0.42) | CYP3A4MEP1BCYP2C9CYP2C19 | |
| SCHEMBL13983342 | 0.84 | CYP3A4 (0.53) | CYP3A4CYP2C9CYP2C19ALDH1A1HTT | |
| SCHEMBL4752685 | 0.81 | MEP1B (0.38) | CYP3A4MEP1BCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL1342509 | 0.80 | CYP3A4 (0.51) | CYP3A4CYP2C9CYP2C19GPR35TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293778-B2 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC (US) | 2012-10-23 | — | — | US | disclosed |
| EP-1773790-B1 | BENZYLTRIAZOLONE COMPOUNDS AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2012-08-15 | — | — | EP | disclosed |
| US-20110207688-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | DUNN JAMES PATRICK | 2011-08-25 | — | — | US | disclosed |
| US-7666891-B2 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC (US) | 2010-02-23 | — | — | US | disclosed |
| US-7625897-B2 | Non-nucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC (US) | 2009-12-01 | — | — | US | disclosed |
| US-7625897-B2 | Non-nucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC (US) | 2009-12-01 | — | — | US | disclosed |
| US-7625897-B2 | Non-nucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC (US) | 2009-12-01 | — | — | US | disclosed |
| EP-1937651-B1 | NNRT INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-12-24 | — | — | EP | disclosed |
| WO-2008157273-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008157330-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |
| EP-1937651-A1 | NNRT INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-07-02 | — | — | EP | disclosed |
| EP-1773790-A1 | BENZYLTRIAZOLONE COMPOUNDS AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-04-18 | — | — | EP | disclosed |
| WO-2007039463-A1 | NNRT INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-04-12 | — | — | WO | disclosed |
| US-20070078128-A1 | Non-nucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC | 2007-04-05 | — | — | US | disclosed |
| US-20070078128-A1 | Non-nucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC | 2007-04-05 | — | — | US | disclosed |
| US-20070078128-A1 | Non-nucleoside reverse transcriptase inhibitors | ROCHE PALO ALTO LLC | 2007-04-05 | — | — | US | disclosed |
| US-20060025462-A1 | Heterocyclic antiviral compounds | ROCHE PALO ALTO LLC | 2006-02-02 | — | — | US | disclosed |
| WO-2006010545-A1 | BENZYLTRIAZOLONE COMPOUNDS AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078128-A1 | Non-nucleoside reverse transcriptase inhibitors | SAMHD1, HPRT1, RTF1 | CYP3A4 350/4885MEP1B 2164/4885CYP2C9 1239/4885 |
| US-20110207688-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | MAVS, IRF3, ZC3HAV1 | CYP3A4 114/4885MEP1B 1403/4885CYP2C9 942/4885 |
| US-20060025462-A1 | Heterocyclic antiviral compounds | MAVS, IRF3, ZC3HAV1 | CYP3A4 893/4885MEP1B 433/4885CYP2C9 1216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.