Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 7/20 | 0.39 |
| ▸ | FNTB | P49356 | 6/20 | 0.39 |
| ▸ | MGLL | Q99685 | 4/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 2/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753292 | 0.83 | CYP2C19 (0.41) | CYP2C19POLBMGLLPPARGGABRA1 | |
| SCHEMBL4750792 | 0.81 | POLB (0.52) | CYP2C19POLBPPARGGABRA1GABRG2 | |
| SCHEMBL4750996 | 0.70 | ALDH1A1 (0.45) | CYP2C19POLBLMNAMAPT | |
| SCHEMBL4751021 | 0.69 | SMN1; SMN2 (0.38) | CYP2C19POLBPPARGLMNAMAPT | |
| SCHEMBL8576502 | 0.66 | PARP1 (0.50) | POLBFNTAFNTBMGLL | |
| SCHEMBL1976542 | 0.65 | POLB (0.65) | CYP2C19POLBLMNAMAPT | |
| SCHEMBL4751002 | 0.64 | ALDH1A1 (0.47) | — | |
| SCHEMBL4287420 | 0.64 | S1PR4 (0.38) | FNTAFNTBLMNA | |
| SCHEMBL4753147 | 0.63 | ALDH1A1 (0.45) | POLBPPARGLMNAMAPT | |
| SCHEMBL4290228 | 0.63 | MAPT (0.51) | LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |