Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 2/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CCR3 | P51677 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5311579 | 1.00 | LMNA (0.34) | LMNAHTTNPSR1TP53CETP | |
| SCHEMBL4359839 | 0.83 | ADORA2A (0.36) | LMNAHTTNPSR1TP53CETP | |
| SCHEMBL4359842 | 0.83 | ADORA2A (0.36) | LMNAHTTNPSR1TP53CETP | |
| SCHEMBL475536 | 0.78 | KLK7 (0.38) | NPSR1MAPTNR1H2NR1H3GPR119 | |
| SCHEMBL4368961 | 0.71 | ROCK2 (0.37) | LMNALIPEGHSRMAPTSMN1; SMN2 | |
| SCHEMBL4368964 | 0.71 | ROCK2 (0.37) | LMNALIPEGHSRMAPTSMN1; SMN2 | |
| SCHEMBL8293034 | 0.71 | BACE1 (0.39) | GPR119 | |
| SCHEMBL28466909 | 0.69 | ALDH1A1 (0.44) | LMNAHTTTP53LIPEMAPT | |
| SCHEMBL12741933 | 0.69 | BACE1 (0.42) | — | |
| SCHEMBL5153000 | 0.68 | OPRD1 (0.42) | NR1H2NR1H3GPR119MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |