Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755173 | 0.92 | LMNA (0.45) | BRD9LMNATNIKMEN1KMT2A | |
| SCHEMBL4753849 | 0.91 | BRD9 (0.47) | BRD9LMNAPIK3C2BTNIKMEN1 | |
| SCHEMBL4753246 | 0.74 | HRH3 (0.40) | MEN1KMT2A | |
| SCHEMBL4755593 | 0.73 | CYP3A4 (0.58) | — | |
| SCHEMBL4755038 | 0.68 | TRPV1 (0.37) | — | |
| SCHEMBL3558933 | 0.68 | KDM4E (0.49) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL4755121 | 0.67 | CYP3A4 (0.56) | BRD9LMNAMEN1KMT2APKM | |
| SCHEMBL4753629 | 0.67 | BRD9 (0.41) | BRD9LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6655920 | 0.66 | CYP3A4 (0.46) | LMNAMEN1KMT2AGLASMN1; SMN2 | |
| SCHEMBL4664696 | 0.66 | CA12 (0.51) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001214-A2 | THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE, ISOXAZOLO[5,4-D]PYRIMIDIN-4(5H)-ONE AND ISOTHIAZOLO[5,4-D]PYRIMIDIN-4(5H)-ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-12-31 | — | — | WO | disclosed |
| WO-2008151927-A2 | 6-N-SUBSTITUTED BENZ IMIDAZOLE DERIVATIVES AS ACID PUMP ANTAGONISTS | NYCOMED GMBH (DE) | 2008-12-18 | — | — | WO | disclosed |