Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | MMP10 | P09238 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | SPR | P35270 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755551 | 1.00 | MAPT (0.34) | MAPTTP53POLBAPPBACE1 | |
| SCHEMBL4755594 | 0.91 | DRD1 (0.37) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL4755592 | 0.91 | DRD1 (0.37) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL4755656 | 0.89 | MEN1 (0.39) | MAPTTP53POLBHCAR1MCHR1 | |
| SCHEMBL4755659 | 0.89 | MEN1 (0.39) | MAPTTP53POLBHCAR1MCHR1 | |
| SCHEMBL4755166 | 0.88 | AVPR1A (0.39) | TP53POLBMCHR1ALDH1A1KMT2A | |
| SCHEMBL4755169 | 0.88 | AVPR1A (0.39) | TP53POLBMCHR1ALDH1A1KMT2A | |
| SCHEMBL13985302 | 0.88 | TSHR (0.31) | HCAR1TSHRSPRAVPR1A | |
| SCHEMBL4755213 | 0.88 | DRD1 (0.40) | POLBHCAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL4755215 | 0.88 | DRD1 (0.40) | POLBHCAR1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | claimed |