Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | USP14 | P54578 | 11/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.35 |
| ▸ | USP5 | P45974 | 1/20 | 0.34 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
| ▸ | LCAT | P04180 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | ICMT | O60725 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13985226 | 0.86 | TBK1 (0.33) | DRD2DRD3KCNH2 | |
| SCHEMBL4755635 | 0.86 | AVPR1A (0.38) | NOTUMDRD2DRD3KCNH2 | |
| SCHEMBL4755639 | 0.86 | AVPR1A (0.38) | NOTUMDRD2DRD3KCNH2 | |
| SCHEMBL13985520 | 0.85 | USP14 (0.38) | USP14HSD11B1DRD2DRD4DRD3 | |
| SCHEMBL13985527 | 0.83 | HSD11B1 (0.36) | USP14HSD11B1DRD2DRD4DRD3 | |
| SCHEMBL13985415 | 0.79 | AVPR1A (0.36) | NOTUMDRD2DRD3KCNH2 | |
| SCHEMBL13985299 | 0.78 | MCHR1 (0.35) | SCN9A | |
| SCHEMBL13985417 | 0.77 | HSD11B1 (0.37) | USP14HSD11B1DRD2DRD4DRD3 | |
| SCHEMBL4755622 | 0.77 | AVPR1A (0.37) | DRD2DRD3KCNH2 | |
| SCHEMBL4755627 | 0.77 | AVPR1A (0.37) | DRD2DRD3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156607-A1 | SUBSTITUTED PYRIMIDINONES | NEUROGEN CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |