SCHEMBL4756437

SCHEMBL4756437

O=C(Oc1ccccc1-c1ccc([N+](=O)[O-])cc1[N+](=O)[O-])C(=O)Oc1ccccc1-c1ccc([N+](=O)[O-])cc1[N+](=O)[O-]

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSPB1 P04792 3/20 0.48
CES2 O00748 1/20 0.46
PTPRC P08575 2/20 0.45
BCHE P06276 1/20 0.45
ACHE P22303 1/20 0.45
CES1 P23141 1/20 0.45
S100A4 P26447 1/20 0.45
GPR35 Q9HC97 2/20 0.45
ALDH1A1 P00352 1/20 0.45
TP53 P04637 1/20 0.45
HPGD P15428 1/20 0.45
TSHR P16473 1/20 0.45
MAPK1 P28482 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
MAPT P10636 3/20 0.44
HSP90AA1 P07900 1/20 0.44
CDK5 Q00535 1/20 0.44
CDK5R1 Q15078 1/20 0.44
NCOA1 Q15788 1/20 0.44
NCOA3 Q9Y6Q9 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8065659 0.91 HSPB1 (0.48) HSPB1CES2PTPRCBCHEACHE
SCHEMBL8065660 0.90 CES2 (0.48) HSPB1CES2PTPRCBCHEACHE
SCHEMBL8065662 0.90 CES2 (0.48) HSPB1CES2PTPRCBCHEACHE
SCHEMBL427368 0.80 ALDH1A1 (0.55) HSPB1CES2GPR35ALDH1A1TP53
SCHEMBL29821424 0.80 ALDH1A1 (0.55) HSPB1CES2GPR35ALDH1A1TP53
SCHEMBL10748570 0.80 PTPRC (0.58) CES2PTPRCBCHEACHECES1
SCHEMBL395708 0.79 ALDH1A1 (0.54) HSPB1PTPRCBCHEACHECES1
SCHEMBL5958796 0.78 TDP1 (0.65) PTPRCBCHEACHECES1S100A4
SCHEMBL619337 0.77 GPR35 (0.55) HSPB1CES2GPR35ALDH1A1TP53
SCHEMBL30459424 0.77 GPR35 (0.55) HSPB1CES2GPR35ALDH1A1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008147381-A1 DETECTION OF PEROXIDE-BASED EXPLOSIVES USING CHEMILUMINESCENCE REDXDEFENSE, LLC (US) 2008-12-04 WO disclosed