SCHEMBL4756578

SCHEMBL4756578

Cc1[c]sc(-c2ccc(F)cc2)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYK2 P29597 1/20 0.37
HSD17B1 P14061 1/20 0.37
HSD17B2 P37059 1/20 0.37
ACHE P22303 2/20 0.36
NPC1 O15118 3/20 0.35
RAB9A P51151 3/20 0.35
KDM4E B2RXH2 3/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
MAPT P10636 1/20 0.35
IKBKB O14920 5/20 0.34
ALDH1A1 P00352 2/20 0.34
HPGD P15428 1/20 0.34
CHUK O15111 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
APP P05067 1/20 0.33
TP53 P04637 1/20 0.32
MAPK14 Q16539 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL694864 0.83 ESR1 (0.37) HSD17B1HSD17B2ACHENPC1RAB9A
SCHEMBL4756537 0.83 HSD17B1 (0.45) HSD17B1HSD17B2ACHEKDM4EMAPT
SCHEMBL4757541 0.80 MAPT (0.37) NPC1RAB9AKDM4EMAPTIKBKB
SCHEMBL694645 0.79 HSD17B1 (0.35) HSD17B1HSD17B2NPC1RAB9AKDM4E
SCHEMBL5254457 0.76 ESR2 (0.36) PTGS2
SCHEMBL4757273 0.74 ACHE (0.41) HSD17B1HSD17B2ACHENPC1RAB9A
SCHEMBL698326 0.66 ACHE (0.42) ACHENPC1RAB9AKDM4EMAPT
SCHEMBL22946430 0.65 ESR1 (0.44) TYK2HSD17B1HSD17B2ACHENPC1
SCHEMBL695512 0.64 ALDH1A1 (0.38) NPC1RAB9AKDM4ESMN1; SMN2MAPT
SCHEMBL7864148 0.64 ACHE (0.36) ACHEAPP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008126684-A2 AGRICULTURAL COMPOSITION FOR CONTROLLING OR PREVENTING PLANT DISEASES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2008-10-23 WO disclosed