Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7856355 | 0.77 | ACHE (0.30) | ACHE | |
| SCHEMBL4756578 | 0.64 | TYK2 (0.37) | ACHEAPP | |
| SCHEMBL693996 | 0.64 | PTGS2 (0.36) | ACHE | |
| SCHEMBL17626168 | 0.63 | ALDH1A1 (0.38) | ACHEAPP | |
| SCHEMBL693755 | 0.63 | APP (0.42) | ACHEAPP | |
| SCHEMBL9649418 | 0.63 | ACHE (0.34) | ACHE | |
| SCHEMBL15977141 | 0.61 | ACHE (0.48) | ACHE | |
| SCHEMBL9646797 | 0.60 | ACHE (0.32) | ACHE | |
| SCHEMBL10337645 | 0.60 | BCL2L1 (0.55) | ACHE | |
| SCHEMBL197346 | 0.60 | BCL2L1 (0.55) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140858-A2 | ARYLPROPENYLIMIDAZOLES AS FARNESYL-PROTEIN TRANSFERASE INHIBITORS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039716-A2 | ARYLPROPENYLIMIDAZOLES AS FARNESYL-PROTEIN TRANSFERASE INHIBITORS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | disclosed |