SCHEMBL4757520

SCHEMBL4757520

NC(=O)C(CC1C2CCC1CN(Cc1ccccc1)C2)(c1ccccc1)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 3/20 0.48
GRIN2B Q13224 2/20 0.43
S1PR1 P21453 1/20 0.43
S1PR5 Q9H228 1/20 0.43
CHRM2 P08172 1/20 0.42
FUCA1 P04066 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4756802 0.87 CHRM3 (0.47) CHRM3GRIN2BS1PR1S1PR5CHRM2
SCHEMBL4790247 0.84 SIGMAR1 (0.48)
SCHEMBL4755473 0.83 GRIN2B (0.40) GRIN2BS1PR1S1PR5FUCA1
SCHEMBL4788078 0.81 CHRM3 (0.43) CHRM3GRIN2BCHRM2
SCHEMBL8878260 0.80 CHRM3 (0.56) CHRM3
SCHEMBL20399839 0.79 GRIN2B (0.49) GRIN2BS1PR1S1PR5FUCA1
SCHEMBL4757528 0.78 DRD2 (0.42) GRIN2BFUCA1
SCHEMBL4756753 0.78 CHRM3 (0.50) CHRM3CHRM2
Water SCHEMBL10720338 0.77 BCHE (0.51) CHRM3
SCHEMBL4757732 0.76 S1PR5 (0.47) CHRM3GRIN2BS1PR1S1PR5CHRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008117229-A1 MUSCARINIC RECEPTOR ANTAGONISTS RANBAXY LABORATORIES LIMITED (IN) 2008-10-02 WO disclosed