Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 8/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755128 | 0.88 | MAPK14 (0.44) | DDR1MGLLMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4758264 | 0.83 | WDR91 (0.40) | DDR1MGLLMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4756997 | 0.80 | MEN1 (0.48) | MEN1KMT2AWDR5LMNAMAPK1 | |
| SCHEMBL4758284 | 0.78 | SMN1; SMN2 (0.47) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4755079 | 0.78 | DDR1 (0.47) | HDAC3HDAC8DDR1KMT2ALMNA | |
| SCHEMBL4758236 | 0.76 | DDR1 (0.34) | DDR1 | |
| SCHEMBL4755723 | 0.73 | CSF1R (0.48) | DDR1LMNA | |
| SCHEMBL4755065 | 0.72 | KAT6A (0.39) | MEN1KMT2ASMN1; SMN2LMNAMAPK1 | |
| SCHEMBL545939 | 0.72 | TPMT (0.52) | MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL1482084 | 0.72 | BCL2A1 (0.44) | DDR1MEN1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009000819-A1 | 5-PHENYL-1,3,4-OXADIAZOL-2-YL-ACETYL-4-PIPERIDINYL DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009000819-A1 | 5-PHENYL-1,3,4-OXADIAZOL-2-YL-ACETYL-4-PIPERIDINYL DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-12-31 | — | — | WO | disclosed |