Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SHMT2 | P34897 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 8/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | DAGLA | Q9Y4D2 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL219441 | 0.78 | POLB (0.48) | POLBSHMT2LMNATHRBFAAH | |
| SCHEMBL7992191 | 0.74 | TP53 (0.51) | POLBSHMT2LMNATHRBFAAH | |
| SCHEMBL1272691 | 0.72 | FAAH (0.45) | LMNAFAAHTP53NPC1RAB9A | |
| SCHEMBL3963517 | 0.69 | FAAH (0.62) | FAAHDAGLA | |
| SCHEMBL9210293 | 0.69 | LMNA (0.65) | POLBSHMT2LMNATHRBTP53 | |
| SCHEMBL9212294 | 0.69 | SHMT2 (0.51) | POLBSHMT2LMNATHRBFAAH | |
| SCHEMBL316306 | 0.69 | KDM4E (0.53) | FAAHTP53NPC1RAB9ADAGLA | |
| SCHEMBL3407130 | 0.68 | SHMT2 (0.56) | POLBSHMT2LMNATHRBTP53 | |
| SCHEMBL1427654 | 0.66 | NPC1 (0.51) | FAAHTP53NPC1RAB9ADAGLA | |
| SCHEMBL1272689 | 0.66 | FAAH (0.42) | FAAHNPC1RAB9ADAGLAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910380-A1 | OXAZOLOPYRIDINE DERIVATIVES AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007019417-A1 | OXAZOLOPYRIDINE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |