Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mivazerol SCHEMBL593708 | 0.87 | PARP1 (0.39) | PARP1CSNK1A1TYRO3DYRK1BALDH1A1 | |
| Mivazerol SCHEMBL8097939 | 0.87 | PARP1 (0.39) | PARP1CSNK1A1TYRO3DYRK1BALDH1A1 | |
| Mivazerol SCHEMBL8865135 | 0.86 | PARP1 (0.38) | PARP1CSNK1A1TYRO3DYRK1BALDH1A1 | |
| SCHEMBL9647633 | 0.83 | PDE10A (0.39) | PARP1KDM4EMEN1KMT2AAURKA | |
| Hydrochloric Acid SCHEMBL10401640 | 0.82 | PDE10A (0.38) | PARP1KDM4EMEN1KMT2AAURKA | |
| SCHEMBL9645530 | 0.80 | CCNE2 (0.37) | PARP1ALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL9647479 | 0.77 | P2RX7 (0.39) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL9518487 | 0.77 | HMGB1 (0.48) | ALDH1A1KDM4ETSHRHPGDHSD17B10 | |
| SCHEMBL29818128 | 0.76 | PARP10 (0.48) | PARP1ALDH1A1KDM4ETSHRHPGD | |
| SCHEMBL166483 | 0.76 | PARP10 (0.48) | PARP1ALDH1A1KDM4ETSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928879-A2 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | Brystol-Myers Squibb Company (US) | 2008-06-11 | — | — | EP | claimed |
| WO-2007038314-A2 | FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-05 | — | — | WO | claimed |